4/10/2002 • Effect of Hypericum perforatum (St John's Wort) in Major Depressive Disorder

4/10/2002 • Effect of Hypericum perforatum (St John’s Wort) in Major Depressive Disorder

David J. Kupfer, MD, Department of Psychiatry, University of Pittsburgh Medical School, Western Psychiatric Institute and Clinic, 3811 O’Hara St, Pittsburgh, PA 15213 (e-mail: kupferdj@msx.upmc.edu).

JAMA Vol. 287 No. 14

This study fails to support the efficacy of H perforatum in moderately severe major depression. The result may be due to low assay sensitivity of the trial, but the complete absence of trends suggestive of efficacy for H perforatum is noteworthy.

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