St. John’s Wort and Acute Insomnia

“SJW must be as powerful a serotonergic as Prozac.”

 

I was so interested when I saw your web site, because from what everyone is saying, serotonin should be added to our drinking supply. Yet not enough is truly known about the brain.

Here is my story. It’s not entirely related to a drug per se, but to St. John’s Wort. I took SJW extract for three weeks in November, three droppers full a day, hoping to stave off winter depression before it hit. I then developed SEVERE insomnia that landed me in the ER twice, and then in the Psych unit. Had a sleep study to no avail. Since then I haven’t been able to sleep without ambien or halcion, despite having no prior history of insomnia. And they keep giving me more serotonergic drugs! I can’t see what it could be besides the St. John’s Wort! And I am only 22!

Zoloft was the worst drug they put me on, and gave me a dissociative panic attack for days on end. I don’t know exactly what my disorder is, but I had a deranged SPECT scan with massive overactivity. Serotonin is a double-edged sword. Watch out! All the research is definitely not in on this one. When I was younger and used to do LSD I had a lot of the same effects that SSRI’s give. They are not that dissimilar.

I would be highly interested if you ever run across anyone who had a severe disabling insomnia somehow induced by excess serotonin. I have talked to one person who had exactly the same thing happen, after a few Prozac, and it turned out they also had a carcinoid syndrome. Now, I know I don’t have this, but I don’t know how to explain any of what I have been through without mentioning the St. John’s Wort, because until that day I was 100% fine, and since then I have been unable to sleep and feeling restless. They had put me on tricyclic antidepressants and then several different SSRI’s which honestly haven’t improved things, and which I secretly discontinued. It’s not like I am depressed anyway, and in fact was in the Psych Hospital for sleep deprivation and released because they couldn’t find any evidence of a mental problem. They said maybe I was manic, but I wasn’t really hyper and had no response to Lithium or Depakote. Then they withdrew that diagnosis, only to say they didn’t know what was wrong with me.

But the thing about the SJW is this: I was on it for about three weeks of a black mood, when I honestly felt my mood lift… then I called everyone and said, “Gee this stuff really works!” Then within days the massive insomnia came. Now my mood is not so great, and I still can’t sleep. So I fail to see what induced it otherwise. All in all it’s weird. SJW must be as powerful a serotonergic as Prozac. I don’t think, if it’s so powerful, that it could really be free of side effects, even if it is natural. That is a rather grandiose claim, made by Howard (? Harold) Bloomfield, the doc who did all the SJW research. My three cents:)

Note from Ann Blake-Tracy:

Something to consider is that “Sleepless in California” had used a drug (LSD) in the past that produces high levels of serotonin. It may be that St. John’s Wort used by someone who has higher levels of serotonin already may find that they have adverse reactions to St. John’s Wort. This would also raise questions about those who have previously used an SSRI using St. John’s Wort. And to answer the question about higher levels of serotonin and insomnia, I refer you to the information in my book PROZAC: PANACEA OR PANDORA? which demonstrates that high levels of serotonin will lower the metabolism of serotonin and results in insomnia.

(Sleepless in California)

Years 2000 and Prior

This is Survivor Story number 81.
Total number of stories in current database is 96

 

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ZOLOFT: MULTIPLE LAWSUITS FILED FOR MULTIPLE BIRTH DEFECTS

Zoloft-mother-and-child[1]

ZOLOFT: MULTIPLE LAWSUITS FILED FOR MULTIPLE BIRTH DEFECTS

I do not believe it is clear to many people how serious these SSRI birth defect cases really are. This is to give you an idea of just how serious the birth defect cases are going against these drug companies…

Child was born with multiple birth defects…The complainant states that she took Zoloft throughout her pregnancy after it was prescribed by her treating physicians. She gave birth to a child with numerous congenital birth defects. The baby has been diagnosed with spina bifida, scoliosis, vater syndrome, tracheoesophageal fistula, and mitral valve regurgitation.

CASE #1

New Jersey Woman Files Zoloft Birth Defects Lawsuit

Perry Larkin | November 6th, 2012 | Posted in Zoloft Lawsuits

A New Jersey woman filed a new Zoloft litigation on October 17, 2012 seeking damages against manufacturer Pfizer, Inc. According to the filing the woman took the antidepressant Zoloft during her pregnancy and it caused multiple birth defects in her newborn son.

The case was filed in the U.S. District Court, Southern District of New York (Foley Square). She makes complaints of product liability, defective design, failure to warn, negligence and misrepresentation and seeks punitive and actual damages.

Zoloft accused of showing “willful disregard” to informing the public of risks

According to studies, Zoloft has long been linked to birth defects in newborns. In spite of FDA regulations that the new medical evidence requires Pfizer to update the warning label, the company has yet to do so.

The plaintiff’s attorney states that the company showed a willful disregard to informing the medical community and public of the risk of congenital birth defects due to Zoloft and this caused permanent harm to his client’s son. The label still fails to warn of the dangers and risks of congenital birth defects of Zoloft if it’s taken during pregnancy.

The plaintiff claims that her baby suffered from the following side effects of Zoloft: spina bifida, vater syndrome, clubfoot and other related defects.

Pfizer alleged to have known of side effects as early as 2007

The lawsuit alleges that Pfizer carelessly marketed the product and failed to provide sufficient warning as to the possible side effects to pregnant women. This case joins other designated cases for the pilot program of the district court, which aims to address complex civil cases.

The complaint says that in 2007, Pfizer knew that selective serotonin reuptake inhibitors (SSRIs) like Zoloft doubled the risk of septal heart defects in babies who were born to mothers who took the medication. In studies published in the New England Journal of Medicine, it indicates that a four-fold increase in heart defects was connected to pregnant women using Zoloft during their first trimester. Other studies showed that using the medication while pregnant is also linked to a higher occurrence of heart malformation.

Child was born with multiple birth defects

The complainant states that she took Zoloft throughout her pregnancy after it was prescribed by her treating physicians. She gave birth to a child with numerous congenital birth defects. The baby has been diagnosed with spina bifida, scoliosis, vater syndrome, tracheoesophageal fistula, and mitral valve regurgitation.

The plaintiff seeks compensation for medical costs, as well as punitive and special damages.

injurylawyer-news.com/2012/11/new-jersey-woman-files-zoloft-birth-defects-lawsuit/

CASE #2

Zoloft Caused Daughter’s Birth Defects, Tennessee Parents Claim in Lawsuit

Tracy Ray | October 24th, 2012 | Posted in Zoloft Lawsuits

In a lawsuit against Pfizer that was recently added to the Zoloft MDL, parents Michael and Shana Reid of Tennessee charge that their daughter was born with birth defects resulting from Zoloft. The Reids originally filed their lawsuit on June 8, 2012, in the Court of Common Pleas in Philadelphia County, and the case was transferred to the Zoloft MDL in the U.S. District Court, Eastern District of Pennsylvania, on August 16, 2012.

Baby needed surgery for life-threatening defects

According to the Reid’s lawsuit, Shana Reid was prescribed Zoloft by her physician during her pregnancy. She read the drug’s warning label, but did not see anything about birth defects, so she trusted that the antidepressant was safe to use while pregnant. Had she been warned about the risk of birth defects resulting from Zoloft, she would not have taken it during her pregnancy, she states in the lawsuit.

The Reid’s baby was born on October 14, 2004 with life-threatening congenital birth defects, the lawsuit states. As a result, the child has undergone corrective surgery and is likely to require further surgeries in future.

Plaintiffs accuse Pfizer of failure to warn mothers of Zoloft’s risks

The Reid’s lawsuit alleges that Pfizer was aware of the risk of side effects after taking Zoloft, but failed to adequately warn the public or the medical community. Their lawsuit charges that Pfizer’s marketing and advertising for Zoloft misled pregnant women and their doctors by giving inaccurate or misleading information about the danger Zoloft poses to a fetus when the drug is taken during pregnancy.

The lawsuit bring counts of failure to warn, design defect, fraud, negligence, gross negligence, negligent design, and breach of warranties. The plaintiffs are seeking compensation in excess of $75,000 in damages.

FDA issued warning about Zoloft birth defects

The FDA issued a warning in July 2006 stating that studies had shown that babies born to mothers who took Zoloft or other SSRI antidepressants during pregnancy were six times more likely to be born with PPHN than babies born to mothers who did not take antidepressants.
The following year, a 2007 study published in the New England Journal of Medicine found that women who took Zoloft during the first trimester had double the risk of giving birth to an infant with heart defects, compared to those who did not take antidepressants.

injurylawyer-news.com/2012/10/zoloft-caused-daughters-birth-defects-tennessee-parents-claim-in-lawsuit/

CASE #3

A Lawsuit Alleging Birth Defects From Zoloft is Filed in Pennsylvania
Perry Larkin | October 15th, 2012 | Posted in Zoloft Lawsuits
On September 10, 2012, a new lawsuit alleging birth defects from the use of Zoloft while pregnant was filed on behalf of ten plaintiffs by Zoloft attorneys. The case, Lentz et. Al. v. Pfizer Inc., was filed in the U.S. District Court for the Eastern District of Pennsylvania and alleges that the antidepressant Zoloft (sertraline) is responsible for the birth defects in their children.

This lawsuit joins the increasing number of plaintiffs who are seeking compensation for the alleged problems as a result of the medication.

Pfizer is accused of knowing of the risk of birth defects and failing to alert the public

The lawsuit alleges that Pfizer knew of the possibility of birth defects from preclinical and published studies and took no action to properly study the drug and its aftereffects. In addition, they chose not to publish these studies due to the revelation of increased risks with the drug. The manufacturer is accused of concealing, suppressing the results, and failing to warn consumers of the potential dangers. Pfizer continues to deny these accusations.

Many side effects from Zoloft can affect the heart, the gastrointestinal system, and cranial malformations

The children were born between 1998 and 2011. A correlation was demonstrated in studies between 2007 and 2009 that indicated the increased risk of birth defects when women take Zoloft while pregnant, but the plaintiffs were unaware of these studies. The plaintiffs claim that if they’d known of the risks, they never would have taken the drug.
Some of the side effects resulting from Zoloft use described in the lawsuit include gastrointestinal problems such as anteriorly displaced anus and omphalocele; heart defects such as right-sided aortic arch, patent ductus arteriosus, cleft mitral valve, transposition of the great arteries, atrial and ventrical septal defects, anomalous pulmonary venous return, and aotrtic stenosis; and craniofacial malformations such as cleft lip and palate, and multiple-suture craniosynostosis.

Pfizer’s safety information posted online doesn’t mention birth defects
On their website, Pfizer has posted “Important Safety Information” about possible complications of Zoloft, but doesn’t specifically mention birth defects. The site does state that “[w]omen who are pregnant, plan to become pregnant, or who are breastfeeding should not take any antidepressant without consulting their doctor,” but to date doesn’t acknowledge any risk of birth defects, nor does it indicate that Zoloft poses any risk to a pregnancy that other antidepressants don’t also pose.

injurylawyer-news.com/2012/10/a-lawsuit-alleging-birth-defects-from-zoloft-is-filed-in-pennsylvania/

CASE #4

Zoloft Drugmaker Blamed for Child Death

Elise Kramer | October 11th, 2012 | Posted in Zoloft Lawsuits

A New York couple has filed a lawsuit against Zoloft drug maker Pfizer, claiming that the antidepressant Zoloft is responsible for the birth defects experienced by their deceased son. The lawsuit was filed on August 17, 2012, in the United States’ District Court for the Eastern District of Pennsylvania, where the current Zoloft multidistrict litigation case is taking place. Jessica and Shawn Coon are claiming that Zoloft was responsible for the side effects experienced by their child, as Jessica took the medication during her pregnancy; they claim that they were not adequately informed of potential side effects associated with the medication at the time.

Negligence claimed by couple

The plaintiffs claim that the deceased minor, known as J.A.C., was born with congenital heart defects caused by birth defects after Zoloft use. He passed away just one month after he was born at the West Chester Medical Center in New York. They claim that because of Pfizer’s negligence and misrepresentation, Jessica Coon continued to take the SSRI drug Zoloft while she was pregnant with her child, which resulted in the birth defects he suffered and in his subsequent death.

The lawsuit claims that Pfizer and its subsidiaries, including Greenstone LLC, did not demonstrate reasonable care in the production, marketing, and distribution of their antidepressant, which caused a number of patients to suffer from birth defects as a result of the drug’s use by pregnant mothers. A number of studies have shown that Zoloft can be linked to an increased risk in birth defects, including PPHN and congenital heart disorders, which can be fatal in serious cases.

Numerous birth defects associated with antidepressant

The growing number of plaintiffs who have chosen to file a birth defects lawsuit related to Zoloft indicates the serious concern about birth defects related to the drug. Studies published in the New England Journal of Medicine revealed that infants born to women taking SSRI medications such as Zoloft were 50 percent more likely to develop heart defects and other serious heart problems.

injurylawyer-news.com/2012/10/zoloft-drugmaker-blamed-for-child-death/

About the Author: Ann Blake Tracy is the author of PROZAC: PANACEA OR PANDORA? –OUR SEROTONIN NIGHTMARE!, and the director of the International Coalition For Drug Awareness [www.drugawareness.org]. She has testified before the FDA and has testified as an expert in legal cases involving serotonergic medications since 1992.

BOOK: Prozac: Panacea or Pandora? – Our Serotonin Nightmare! Anything you ever wanted to know about antidepressants is there along with everything drug companies hope you never find out about these drugs. SAFE WITHDRAWAL CD “Help! I Can’t Get Off My Antidepressant!” on how to safely withdraw from antidepressants & most psychiatric medications is saving lives! Both available at www.drugawareness.org

BOOK TESTIMONIALS:

“Very bold & informative”

“Priceless information that is giving me back to me”

“The absolute best reference for antidepressant drugs”

“Well documented & scientifically researched”

““I was stunned at the amount of research Ann Tracy has done on this subject. Few researchers go to as much trouble aggressively gathering information on the adverse reactions of Prozac, Zoloft and other SSRIs.”

WITHDRAWAL HELP CD TESTIMONIALS:

“Ann, I just wanted to let you know from the bottom of my heart how grateful I am God placed you in my life. I am now down to less than 2 mg on my Cymbalta and I have never felt better. I am finally getting my life back. I can feel again and colors have never been brighter. Thanks for all that you do!!” … Amber Weber

“Used your method of weaning off of SSRI’s and applied it to Ambien. Took 6 months but had been on 15 mg for years so what was another 6 months. I have been sleeping without it for 2 weeks and it is the first time I have been able to sleep drug free for 15 years. What a relief to be able to lay down and sleep when I need or want to. Ambien may be necessary for people at times but doctors giving a months worth of it at a time with unlimited refills is a prescription for disaster. It is so damn easy to become dependent on. Thanks for your council Ann.”… Mark Hill

“I’m so thankful for AnnTracy and all her work. Also for taking the time out to talk to me and educate everyone! She has been a blessing to me during this awful time of antidepressant hell!” … Antoinette Beck

1,676 total views, 2 views today

STUDY: 75% OF THOSE TAKING ANTIPSYCHOTIC MEDS SHOW LOSS OF BRAIN MATTER!

elsevier[1]

Our most recent post was on the extreme increase in the use of antipsychotic medications – especially in children: Since 1993 use in children (who have no choice in the decision) skyrocketed by 800%, in teens by 500%, and in adults by 200%. Now a new study just out demonstrates brain damage in 75% of those who take these drugs!!

THE IMPACT UPON SOCIETY

Think it does not affect you because you are not on them? Better think again because we will all pay to care for those suffering brain damage from these drugs in higher taxes, higher insurance rates, disability payments, etc. and in reduced productivity & creativity via the contributions these people could have made to our society had their brains remained intact and functioning.

SEROTONIN-INDUCED OXYGEN DEPRIVATION

PRODUCING CELL DEATH

Of course my first question would be, “How many of those patients tested had previously been on antidepressants BEFORE they were given antipsychotics to treat their antidepressant-induced psychosis which antidepressants are so prone to produce?” Why would I want to know that? Because antidepressants ALSO decrease the blood flow to the brain as will any other drug that increases serotonin. The main function of serotonin is constriction of smooth muscle tissue such as the veins & arteries that carry oxygen to the brain.

CORKSCREW BRAIN CELLS FROM ANTIDEPRESSANTS

As early as a decade ago in February of 2000 Jefferson Medical College in Philadelphia published research indicating that several serotonergic medications within only four days use caused a shriviling up of brain cells or taking on of abnormal corkscrew shapes. (What a nice technical way to express that these drugs literally screw up the brain!) The drugs featured in this research were all serotonergic – the antidepressants Prozac and Zoloft, and the diet drugs Redux and Meridia which have now been pulled from the market due to the brain damage produced by these drugs (see below for that explanation).

BRAIN CELL DEATH? PERMANENT OR TEMPORARY?

The lead researcher in this study concluded: “We don’t know if results with four days of drug treatment are clinically significant,” Dr. Kalia says. “We don’t know if the cells are dying. That’s the key question. We need to do more studies to prove cell death. These effects may be transient and reversible. Or they may be permanent.” (Please see my comments below on the question of permanent damage or temporary.)

POPULAR DIET PILLS PULLED DUE TO BRAIN DAMAGE

Another piece of information few have is the fact that Fen-Phen & Redux were pulled from the market due to the massive brain damage they caused, not the heart valve damage or PPHN that so many assumed was the reason they were pulled from the market. Just two weeks before the removal of those drugs  from the market the National Institutes of Health (NIH) had finished an extensive study on Redux & brain damage which the manufacturer, Wyeth, was suppose to have completed as part of the drug’s approval a full year before.

The NIH study results demonstrated some of the most massive brain damage you could imagine! JAMA published the study August 27 1997, titled, “Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence.”

BRAIN SEROTONIN NEUROTOXICITY?!!

PLEASE note that term in discussing ANY drug that increases serotonin! Make the connection between elevated serotonin and neurotoxicity – brain damage!

Within a couple of weeks after pubication that NIH study the drugs were off the market! But tragically that left MANY patients in horrific cold turkey withdrawal which naturally resulted in many suicides, murder/suicides, and deep depression which most had never suffered from before taking these serotonergic diet pills. These cases went mostly unnoticed or recognized as related to the drugs or the cold turkey withdrawal from these drugs. At that point many of those patients ended up on antidepressants which helped to stop the withdrawal, but of course should be expected to continue the damage to the brain via the excess serotonin they too produce. This is an example of a dangerous senario all those on antidepressants need to be aware of – the potential abrupt withdrawal of the drugs they are taking being pulled with little to no warning.

IS THERE HOPE AFTER SUCH DAMAGE?

I have long contended that this brain damage does not have to be permanent. I do believe there is hope for recovery, but I think you have to work at it. Just stopping the drugs producing the damage is not enough. Please go to www.drugawareness.org/alternatives to see just how many options there are to restoring one’s health and brain function after the use of these drugs. You can even see brain scans before and after some of the treatments showing recovery.

I would also refer all to our website link to alternatives we have found to help and also to a special done by Dr. Sanjay Gupta from CNN, who, after interviewing with him I have much respect for as a brilliant and open minded scientist and good human being. The link to information on that special is located here: http://www.drugawareness.org/cnn-teen-in-coma-from-severe-brain-injury-recovers-with-alternatives/

Read the study on antipsychotics & brain damage, along with references here: www.sciencedirect.com/science/article/pii/S014976341200125X

Read article from Jefferson Medical College on corkscrew shaped brain cells here: http://www.antidepressantsfacts.com/Thomas-Jefferson-University-Hospital.htm

Read NIH study on Fen-Phen & Redux, Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence, here: http://www.ncbi.nlm.nih.gov/pubmed/9272900

 

Ann Blake-Tracy, Executive Director,

International Coalition for Drug Awareness

www.drugawareness.org & www.SSRIstories.com

Author: “Prozac: Panacea or Pandora? – Our Serotonin Nightmare – The Complete Truth of the FullImpact of Antidepressants Upon Us & Our World” & Safe Withdrawal CD “Help! I Can’t Get Off My Antidepressant!”

BOOK:  Prozac: Panacea or Pandora? – Our Serotonin Nightmare! Anything you ever wanted to know about antidepressants is there along with everything drug companies hope you never find out about these drugs. Find the book & the CD “Help! I Can’t Get Off My Antidepressant!” on how to safely withdraw from antidepressants & most psychiatric medications. Available at www.drugawareness.org

BOOK TESTIMONIALS:

“VERY BOLD AND INFORMATIVE”

“PRICELESS INFORMATION THAT IS GIVING ME BACK TO ME”

“THE ABSOLUTE BEST REFERENCE FOR ANTIDEPRESSANT DRUGS”

“WELL DOCUMENTED & SCIENTIFICALLY RESEARCHED”

“I was stunned at the amount of research Ann Blake-Tracy has done on this subject. Few researchers go to as much trouble aggressively gathering information on the adverse reactions of Prozac, Zoloft and other SSRIs.”

WITHDRAWAL HELP CD TESTIMONIALS:

“Ann, I just wanted to let you know from the bottom of my heart how grateful I am God placed you in my life. I am now down to less than 2 mg on my Cymbalta and I have never felt better. I am finally getting my life back. I can feel again and colors have never been brighter. Thanks for all that you do!!” … Amber Weber

“Used your method of weaning off of SSRI’s and applied it to Ambian. Took 6 months but had been on 15 mg for years so what was another 6 months. I have been sleeping without it for 2 weeks and it is the first time I have been able to sleep drug free for 15 years. What a relief to be able to lay down and sleep when I need or want to. Ambien may be necessary for people at times but doctors giving a months worth of it at a time with unlimited refills is a prescription for disaster. It is so damn easy to become dependent on. Thanks for your council Ann.”… Mark Hill

“I’m so thankful for Ann Blake-Tracy and all her work. Also for taking the time out to talk to me and educate everyone! She has been a blessing to me during this awful time of antidepressant hell!

9,316 total views, 16 views today

STOP ANTIDEPRESSANT VIOLENCE from ESCALATING

Tonight I got a call from a close friend I have known for over 20 years. He called to let me know that his 32 year old niece committed suicide on antidepressants today leaving her husband & three children behind. Last week I got a call from another close friend whose son-in-law made several very impulsive serious suicide attempts after taking only one Zoloft. So why you ask do I do what I do in working so hard to educate others to the dangers of these drugs? Because … no matter who you are … antidepressants come through your back door when you are not looking & destroy lives of those you love!!!

This is the link to a site posted by an amazing young man who has been able to accomplish this much from inside a prison cell after he killed his father while on Prozac when he was just a teen: http://www.thesaveproject.com/ I do hope you click on Kurt’s site and watch the video that was a Primetime special we did a few years back. In the video you will see MANY of those I have worked with over the years that have come to be like family to me. I cry everytime I think of the precious lives that have been lost to us all because of these deadly drugs!!!!!

www.thesaveproject.com

TheSaveProject – S.A.V.E. – STOP ANTIDEPRESSANT VIOLENCE from ESCALATING

——

1,656 total views, 3 views today

zoloft

zoloft
George Mooney
I am the father of identical twin boys. The doctors that treated my sons when they were boys warned that if we ever decided to have them placed into care for the handicapped we should not agree to any physcotropic drugs. This is when I became aware of the danger of antidepressant drugs. My wife and I both agreed that this would be the case,
My wife passed away in 1984. I was diagnosed with a ”fatal” melanoma in 1986. My twins were admjtted to a ”care” agency and placed on Prozac for son David, and Zoloft for Douglas. They were placed in homes and ”supervised” which meant that they could not enjoy the freedom they enjoyed at home and were not allowed out of the sight of their caretakers for over twenty years. With the help of anti-drug people I visited a psychotherapist who asked why David was on Prozac, as he opined that David did not have a mental disorder. I then contacted a psychiatrist that asked the same question and agreed to withdraw the Prozac. David has been withdrawn from Prozac for about two years without any ill effects beyond what I precieve as side effect damage.
Douglas’ psychiatrist ignored my certified return reciept letters requesting as legal guardian that he be withdrawn from Zoloft. Douglas developed colon cancer and passed away after fourteen months of terrible suffering. Both my twins were gifted savants.

1,116 total views, 1 views today

prozac/fluoxetine

prozac/fluoxetine
paul pezzack
i started taking fluoxetine a generic form of prozac in january 2006 after being attacked and having my jaw broken.at first i felt ok,i was prescribed 40mg a day.i started to notice that when i went out drinking i could drink a lot more than usual.sometimes i would miss out a tablet or not take them for a bit.i thought it was smoking and or drinking.so i stopped them.i gave up everything but gradually got worse.i stopped taking the prozac in august 2007,i began to feel very dizzy,lethargic,anxious.i went to my doctor and he said i shouldnt have just stopped but it was ok because they have a long half life in the body and therefore taper out on their own.on 24th september 07 i woke with a terrible headache and the room wouldnt stop spinning.i had been getting muscle spasms and hot flushes for a while but just didnt know why.i went to my doctor.he said i had an ear infection and gave me antibiotics.i took it for 2 days and just couldnt believe how i was feeling my body was as heavy as a rock,my head everywhere ,i couldnt think straight at all.i decided it wasnt an ear infection and it must be the prozac and i would try and get off them.i stayed at my mums house and didnt take any for 12 weeks,i would have nightmares,shaking,hot flushes,muscle spasms,rigid muscle and stiffness.,headaches like you wouldnt believe ,a pain in my back like a hot poker had been pushed in there,shaking,shivering,visual impaiment,foggy,feelings of being outside myself or looking through a fisheye lens and incredible urges that i might hurt my mum or myself or anyone else,i cried all the time.it was the most horrific time ever in my life it was everyday allday ,24/7 of pain and anguish..eventually i gave in on december the 6th after reading on the internet that it could take 6 months to get off them.i have had side effects ever since,all the effects i had originally have continued,it has ruined my life and i feel trapped.no doctor ive spoken to believes me,i went the hospital on many ocassions and almost got laughed at because they couldnt find anything wrong.they all say you cant have problems with prozac.they just put it down to a mental health problem and treat you like an idiot.i have considered killing myself many times to get away from the pain.but something in me keeps fighting and i want to be free.i have cut down to one fifth of a tablet now and my side effects are much easier to cope with,but i really feel like i have had no help or advice at all.i have never had anyone advise on how to get off it.i have just taken the tablets apart and cut it down over the past 2 years.even my own family dont think im ill,if it wasnt for my one brother and my mum,who sadly died in november 2009 .i would be dead for definate.i would have been better off being a heroin addict and recieved help and advice.if anyone can give me advice i would be very grateful.im from wales in the uk and it seems totally ignorant to these terrible drugs.good luck to all of the people who try to stop taking them and please remember no matter how hard it gets dont ever give up and give in.together we can fight these evil drugs.

1,475 total views, no views today

Medical News Today: Antidepressants Produce Long-Term Depression

We read in the article below the following statements about long-term use of antidepressants producing long-term depression & withdrawal. Now all these researchers had to do to learn this sooner was read the research in my book when the first edition came out almost 20 years ago. Once again I repeat that the hypothesis behind antidepressants is INCORRECT/BACKWARDS!! And if the hypothesis is backwards the drugs are going to CAUSE what we are being told that they cure!
“. . . there are reasons to believe that antidepressant treatment itself may contribute to a chronic depressive syndrome. . .
In other words, prolonged exposure to antidepressants can induce neuroplastic changes that result in the genesis of antidepressant-induced dysphoric symptoms. The investigators propose the term ‘tardive dysphoria’ to describe such a phenomenon and describe diagnostic criteria for it. Tapering or discontinuing the antidepressant might reverse the dysphoric state. Antidepressant discontinuation may not provide immediate relief. In fact, it is likely that transient symptoms of withdrawal will occur in the initial 2-4 weeks following antidepressant discontinuation or tapering. However, after a prolonged period of antidepressant abstinence, one may see a gradual return to the patient’s baseline.”
Ann Blake-Tracy, Executive Director
International Coalition for Drug Awareness
www.drugawareness.org & www.ssristories.drugawareness.orgAuthor: Prozac: Panacea or Pandora? – Our Serotonin
Nightmare – The Complete Truth of the Full Impact of
Antidepressants Upon Us & Our World & Help! I
Can’t Get Off My Antidepressant!
 
http://www.medicalnewstoday.com/articles/218435.php
A New Troublesome Long-Term Effect Of Antidepressant Drugs; Tardive Dysphoria.
Editor’s Choice
Main Category: Depression
Also Included In: Psychology / Psychiatry
Article Date: 08 Mar 2011 – 0:00 PST

Treatment-resistantdepression (TRD) may be related to inadequate dosing of antidepressants or antidepressant tolerance. Alternatively, there are reasons to believe that antidepressant treatment itself may contribute to a chronic depressive syndrome. This study reports a case of antidepressant discontinuation in a TRD patient, a 67-year-old white man with onset of major depressive illness at the age of 45. He was homozygous for the short form of the serotonin transporter. He was treated off and on until the age of 59 and had been on an antidepressant continuously until the age of 67. Over the previous 2 years he had been depressed without any relief by medication or 2 electroconvulsive treatments. His medications at the time of evaluation included paroxetine 10 mg daily, venlafaxine 75 mg daily and clonazepam 3 mg daily. His 17-item Hamilton depression score was 22. Over the subsequent 6 months, he was started on bupropion and then tapered off all antidepressants, including the bupropion. His Hamilton depression score dropped to 18. The patient was not satisfied with his progress and sought another opinion to restart antidepressants. One year later, on duloxetine 60 mg daily, he continued to complain of unremitting depression.

A possible prodepressant effect of antidepressants has been previously proposed. Fava was the first to suggest that an antidepressant-related neurobiochemical mechanism of increasing vulnerability to depression might play a role in worsening the long-term outcome of the illness. Understanding of potential mechanisms of this phenomenon can be gleaned from observations regarding the short form of the serotonin transporter (5HTTR). Patients with the short form of the 5HTTR and prolonged antidepressant exposure, may be particularly vulnerable to antidepressant-related worsening. In other words, prolonged exposure to antidepressants can induce neuroplastic changes that result in the genesis of antidepressant-induced dysphoric symptoms. The investigators propose the term ‘tardive dysphoria’ to describe such a phenomenon and describe diagnostic criteria for it. Tapering or discontinuing the antidepressant might reverse the dysphoric state. Antidepressant discontinuation may not provide immediate relief. In fact, it is likely that transient symptoms of withdrawal will occur in the initial 2-4 weeks following antidepressant discontinuation or tapering. However, after a prolonged period of antidepressant abstinence, one may see a gradual return to the patient’s baseline.

Source: Journal of Psychotherapy and Psychosomatics, AlphaGalileo Foundation.

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A Decade Later Additional Heightened Concerns About Pharmaceuticals in Water

NOTE FROM Ann Blake-Tracy (www.drugawareness.org):

Would you like a little Prozac or Zoloft with your water???

A Decade Later Additional Heightened Concerns About Pharmaceuticals inWater

An absolutely EXCELLENT article on this issue!!!! This kind of concern was first raised a decade ago in 2000. We sent out the information far and wide then. Clearly few knew enough to be concerned. But now with further study the results are shockingly confirming all we warned of in 2000! Those results are especially telling when it comes to fish being given low doses of Prozac . . . the bizarre changes inbehavior, etc.

DO NOT sit around and say it is only fish, there is no need to worry. Our entire world is balanced with each species playing an extremely important role. We do not survive if they do not survive!

And be sure to note what is said about the chlorine/flouride additives to our water when combined with these drugs! Snyder, the Arizona expert, is stating that we as humans are exposed to more of these disinfecting chemicals in our water than anything while they are so “understudied.” The truth about chemicals is that we know SO LITTLEabout any of them that we have absolutely no idea what we are exposing ourselves and our posterity to and where it could lead us as a society. Tragically the mess inwhich we now find ourselves could be a warning of what is to come if we do not wake up soon to our own insane belief system of “Better Living Through Chemistry”! We are quickly learning that we are far from invincible!!

Find below some of the highlights of this article that need to be emphasized:

– Bryan Brooks has spent a lot of time wading in Pecan Creek, a small Denton stream, searching for mutant fish. For some time, Brooks and his colleagues from the University of North Texas were observing strange things in North Texas fish—males turning into females, for example—but were unable to blame them on traditional waterpollutants like metals. The environmental toxicologists thought the mutations might have something to do with other compounds like pharmaceuticals that were showing up in freshwater streams.

Over time, they collected a bunch of fish and tested their flesh in the lab. Sure enough, they found fluoxetine (Prozac) and sertraline (Zoloft) and their human metabolites in every catfish, crappie and bluegill they tested. It was the first time researchers had proved that these human drugs were showing up in wild fish.

– Toxicologists have just begun the difficult task of figuring out what effects these contaminants might have on human health. A single contaminant might do nothing. Butin combination with others, the effect could be enhanced, particularly for vulnerable groups like children or pregnant women. What sort of health effects arise from complex mixtures of chemicals in drinking water?

Bryan Brooksphoto courtesy Baylor University Bryan Brooks

Bryan Brooks has spent a lot of time wading in Pecan Creek, a small Denton stream, searching for mutant fish. For some time, Brooks and his colleagues from the University of North Texas were observing strange things in North Texas fish—males turning into females, for example—but were unable to blame them on traditional waterpollutants like metals. The environmental toxicologists thought the mutations might have something to do with other compounds like pharmaceuticals that were showing up in freshwater streams.

Over time, they collected a bunch of fish and tested their flesh in the lab. Sure enough, they found fluoxetine (Prozac) and sertraline (Zoloft) and their human metabolites inevery catfish, crappie and bluegill they tested. It was the first time researchers had proved that these human drugs were showing up in wild fish.

Brooks (now at Baylor University) is part of a growing legion of scientists and regulators studying “emerging contaminants,” a loose definition of chemicals that include prescription and over-the-counter drugs, flame retardants, animal hormones, pesticides, plasticizers and cosmetics, to name a few. Many of these unregulated contaminants pass through wastewater treatment plants and end up in streams, exposing fish and other aquatic life to an exotic chemical cocktail.

More worrisome: The same chemical-infused water ends up in our drinking water.

Take Pecan Creek. During dry spells, Pecan Creek consists of effluent from Denton’s wastewater treatment plant. The stream then flows into Lake Lewisville, a drinkingwater supply for millions in Dallas-Fort Worth. The toilet-to-tap phenomenon is becoming more common as cities look to recycled wastewater to offset diminishing freshwater supplies.

Dallas, like dozens of other cities in Texas and around the nation, has detected trace amounts of emerging contaminants in its water supplies.

“You name the compound; somebody has probably found it in somebody’s watersource or the effluent coming out of the [treatment plant],” says Charles Stringer, an assistant director of Dallas Water Utilities.

The same holds for tap water. Unwittingly, Americans are drinking a cornucopia of chemicals—albeit in tiny amounts—that in many cases we know little about.

In the most comprehensive, peer-reviewed study to date, the Southern Nevada WaterAuthority tested the tap water of 15 utilities that collectively serve 28 million Americans. Thirteen had measurable levels of contaminants, including the anti-convulsant phenytoin, the pesticide atrazine and the insecticide DEET.

Such reports have roused public concern and convinced the federal government to take a tentative step. In October, the EPA announced it’s considering pharmaceuticalsfor regulation under the Safe Drinking Water Act.

In Texas, water utilities and elected officials are only beginning to grapple with the problem. A task force created by the Texas Legislature in 2009 is looking into ways to keep pharmaceuticals out of landfills and wastewater systems. On the local level, cities are not required by federal law to test wastewater or drinking water plants for emerging contaminants. Many choose not to, partly out of fear that the results will be misinterpreted.

“If you say you’ve got aspirin in your water at one picogram per liter, somebody says, oh my god there’s aspirin in the water,” Stringer says. “The cities that are trying to be proactive and look at it are getting the hell beat out of them.”

Dallas is proactive, Stringer says. In November, the U.S. Geological Survey published the results of extensive sampling in the Elm Fork of the Trinity River, a drinking watersource for Dallas that is downstream from other cities’ discharges. The scientists also tested the water after it had been treated for people’s taps. The federal agency found that 38 of the 42 most frequently detected compounds in the river water—including the pesticide atrazine, the gasoline additive MTBE (banned in some states) and the toxic insecticide Diazinon, whose sale is illegal for non-agricultural purposes—made it into the tap water. While the concentrations didn’t exceed federal or state standards, the study notes that only half of the detected compounds have human-health benchmarksin those standards.

The city of San Marcos commissioned Texas State University toxicologist Glenn Longley and one of his students to test surface water there for 23 emerging contaminants—pharmaceuticals, fire retardants, fragrances, pesticides and others. While Longley found 18 chemicals in the water, only one—bisphenol A, or BPA, the controversial plasticizer found in Nalgene bottles—made it into the city’s tap water.

Most of these contaminants are not new. Some have been “emerging” in the environment for decades. But the development of ultrasensitive instruments has now enabled scientists to detect the compounds at concentrations down to parts per trillion. It’s as if a powerful new telescope suddenly picked up a galaxy in a previously dark part of the sky—the difference being that these chemicals hit uncomfortably close to home.

Toxicologists have just begun the difficult task of figuring out what effects these contaminants might have on human health. A single contaminant might do nothing. Butin combination with others, the effect could be enhanced, particularly for vulnerable groups like children or pregnant women. What sort of health effects arise from complex mixtures of chemicals in drinking water?

No one knows. One challenge, among many, is that it’s difficult to perform toxicity tests for humans. “It’s not like on the aquatic side,” says Dana Kolpin, head of the U.S. Geological Survey’s Emerging Contaminants in the Environment Project. “We’re doing experiments with biologists where we’re exposing minnows or other organisms to, say, effluent or spike levels. You just can’t do that with humans.”

Shane Snyder, a professor of environmental engineering at the University of Arizona and co-director of the Arizona Laboratory for Emerging Contaminants, says he’s been asked to brief a Congressional committee on this issue. It’s “very difficult” to do a risk assessment for mixtures, he says, especially when chemicals can simultaneously act on different pathways in the body. For example, one substance might damage the liver, while another present at the same time disrupts the endocrine system.

“You could get a more profound effect [collectively] than from each one separately,” says Snyder.

Snyder says there’s far more to learn—and perhaps fear—from what happens when emerging contaminants go through the treatment process. Some seem to disappear, but they could be subtly transformed into something more toxic by widely used disinfectants like chlorine.

“In my mind there is no question that humans are exposed to more disinfection byproducts than any other contaminants through their drinking water,” Snyder says. “Itconcerns me as a scientist and a toxicologist that those classes of compounds are understudied.”

About 20 percent of disinfection byproducts are regulated, Snyder says. Sixty percent haven’t even been identified.

While the effects on humans remain mysterious, the ecological effects of water-borne chemicals—even at extremely low levels—is becoming well established. And those effects can be downright bizarre.

Toxicologists and biologists have linked low concentrations of pharmaceuticals and other emerging contaminants to a host of developmental, reproductive and behavioral problems in aquatic species including algae, mussels, minnows and game fish. Astudy published in 2008 by researchers at Clemson University exposed hybrid striped bass to relatively low levels of Prozac.

The results were depressing—the more Prozac in the water, the longer it took the bass to nail their prey. The fish acted strangely, too, hovering near the surface of the aquarium, sometimes with their dorsal fins poking out of the water. Others floated vertically, tails down and mouths above the water level, like a kid dog-paddling in apool.

Antidepressants like Zoloft and Prozac work in humans by increasing serotonin, anatural chemical that helps regulate brain activity and is linked to feelings of well-being.In bass, among other functions, serotonin plays a pivotal role in feeding behavior. Changes in serotonin levels can tilt the predator-prey balance and affect not just the individual, but potentially the whole ecosystem.

It’s not just antidepressants that can make aquatic life go haywire. Even infinitesimally small amounts of the synthetic estrogen in birth control drugs can induce sex reversalsin male fish and disrupt reproduction. Canadian scientists brought an entire ecosystem to the brink of collapse by introducing estrogen—at levels frequently found inmunicipal wastewater—to an experimental lake in northern Ontario.

In 2008, a researcher for Johnson & Johnson calculated that toxic effects on fish from estrogenic substances could be expected at concentrations as low as 350 parts per quadrillion.

“If you can imagine 350 parts per quadrillion,” Snyder says, “it’s unimaginably small, but yet it can have a measurable impact on fish.”

Snyder points out that well-documented impacts on wildlife are often misinterpreted to mean humans are at risk from the same levels.

“The part where people get a little bit confused is they say, well if it can impact a fish, then certainly it could impact a human,” Snyder says. “That’s just not true. You’re comparing apples to oranges.”

Consider pharmaceuticals. Drug developers are required to submit reams of pharmacological information to the Food and Drug Administration proving their drugs are safe and work as intended. They’re tested on people. The levels found in game fish and drinking water supplies, so far, are thousands of times below therapeutic levels.

Brooks provides an illustration. In a national pilot survey of five effluent-dominated rivers, the highest level of antidepressant he and the EPA found in fish tissue wasabout 19 nanograms of Zoloft per liter in a fish outside Philadelphia.

“It would take me 3,500 meals of that fish to reach one daily dose of sertraline,” Brooks says. Likewise, someone would have to drink millions of liters of tap water to reach a single dose of Zoloft.

“From what I’ve seen in the developed world, I’m just not as concerned about human health right now. I think the highest relative risk is to aquatic life,” he says.

Utility managers are sticking to that point. “What we’ve been told to tell people is that these minute traces of organics are below any known health effects,” Stringer says.

Regardless, Dallas is planning to upgrade its drinking water plants to include ozonation and biological filtration, advanced but costly processes. The utility isn’t doing it primarily to deal with emerging contaminants, but that will be an added benefit.

“What we’re hoping to see is very little organic material coming out and going into the distribution system for consumption,” Stringer says.

If a city wants to eliminate virtually all contaminants, it would need to install advanced systems like reverse osmosis, which is extraordinarily expensive.
That’s not feasible, Snyder says.

“We just can’t put the whole world’s water supply through reverse osmosis because we’re worried about emerging contaminants,” he says. “It’s going to fail. Just on the energy alone, it will fail.”

With 80,000 chemicals registered for use in the United States and new ones coming to market every year, the key could be keeping the most dangerous ones out of the environment in the first place. For thousands of chemicals, there are “zero data” on their toxicity, Brooks says.

The European Union has implemented a sweeping system called Registration, Evaluation and Authorization of Chemicals, or REACH. The system requires testing thousands of old and new chemicals for human and environmental toxicity, and could lead to bans on high-risk chemicals that aren’t regulated in the United States.

Given the power of the pharmaceutical and chemical industries in this country, such asystem seems like a far-off goal. Jacobs, the environmental activist on the Texas pharmaceutical task force, says his group is advocating for something far more modest: manufacturer take-back programs in which consumers could return unused or expired drugs to pharmacies for proper disposal. He says the pharmaceutical interests on the task force are doing their best to discredit the idea.

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