Time Released Prozac for Dogs Approved in the UK

NOTE FROM Ann Blake-Tracy (www.drugawareness.org):

And who did they pay to “cook the books” on this research?!! Was the same
researcher who just plead guilty to falsifying research for GlaxcoThe initial
studies done by Lilly on dogs and cats demonstrated that the animals given

Prozac began to growl and hiss within days on the drug and the behavior
continued until several days AFTER withdrawal of the medication. Those results
would indicate a contraindication for Prozac being given to dogs as they
have for close to two decades now.

The only thing new with Reconcile, the name of the drug in the US, is
that it is a time release Prozac. All the time released change does is make
it FAR MORE difficult to withdraw from. If your dog happens to be a
rapid metabolizer then he/she will metabolize the drug faster than expected and
go into withdrawal before the next dose is given. And according to FDA warnings
you could have a dog that could be going into a withdrawal reactions
of suicide, hostility, or psychosis. . . . We need to do a survey to see
how many dogs are running in front of mack trucks and trains instead of just
chasing cars once they begin taking this medication. 🙂 🙂
🙂 . . . . Back to the seriousness of this issue, this is an
extremely dangerous way for dogs and humans or any other living creature to take
a drug!

____________________________________

At the time, Steve Connell, Eli Lilly’s manager of consumer services for
companion animal health, said that more than 10million US dogs exhibit strange
symptoms from being left alone too long. [Hmmmmm and how many humans and other
living creatures exhibit strange symptoms from being left alone too
long?!!!]

‘Lilly research shows that 10.7million, or up to 17 per cent, of US dogs
suffer from separation anxiety,’ he said. ‘We’re thrilled that our first product
for dogs can help restore the human-pet bond.’

He said research showed that 73 per cent of dogs taking Reconcile and
undergoing therapy showed better behaviour within eight weeks, compared to dogs

receiving therapy alone.

http://www.dailymail.co.uk/news/article-1252672/A-dogs-life-set-easier-day-pet-Prozac-treat-depression.html

A dog’s life set to get easier with once-a-day pet Prozac to treat
depression

By Daniel Martin
Last updated at 8:58 AM on 22nd February
2010

A dog version of the anti-depressant Prozac has been approved for sale to
British pet owners.

The one-a-day tablet, which tastes of beef, is said to help cure ‘canine
compulsive disorder’ and ‘separation anxiety’ brought on by owners’ long
absences during the day.

Symptoms include poor behaviour, whimpering or tail-chasing.

Spaniel looking sad

Down in the doggy dumps:
Once-a-day chewable tablet, which tastes of beef, has been launched in the US to
help dogs beat depression

The drug, called Reconcile, is also designed to curb the compulsive pacing,
chewing and dribbling which its makers claim is a result of depression brought
on by their owners’ long absences.

The anti-depressant Prozac has been used to cure compulsive behaviour in
humans, and works by increasing the brain’s levels of serotonin, a ‘happiness’
chemical.

Trials involving more than 660 mentally-disturbed pets in Europe and the US
produced improvements in behaviour within eight weeks.

Eli Lilly, the drug’s US manufacturer, said: ‘Treatment for companion animals
is a relatively new area for us.’

They point to research which shows that as many as 8 per cent of dogs suffer
from canine compulsive disorder.

Prozac

Pick me up: Prozac

Critics say dogs are now being diagnosed with ‘lifestyle’ illnesses so that
drugs can be marketed to treat them.

Roger Mugford, an animal psychologist, said: ‘Most breakthroughs in dog
behaviour are achieves by carrying a tidbit and using it wisely, not by
drugs.’

Reconcile has now been granted a license by the UK‘s Veterinary Medicines
Directorate.

However, it was first licensed in the US three years ago for separation
anxiety from being left alone for long periods.

The American Food and Drug Administration said it should be taken with
therapy to modify the dog’s behaviour – and should be taken by puppies as young
as six months.

At the time, Steve Connell, Eli Lilly’s manager of consumer services for
companion animal health, said that more than 10million US dogs exhibit strange
symptoms from being left alone too long.

‘Lilly research shows that 10.7million, or up to 17 per cent, of US dogs
suffer from separation anxiety,’ he said. ‘We’re thrilled that our first product
for dogs can help restore the human-pet bond.’

He said research showed that 73 per cent of dogs taking Reconcile and
undergoing therapy showed better behaviour within eight weeks, compared to dogs
receiving therapy alone.

The drug’s website says: ‘While you may not be familiar with canine
separation anxiety, you are probably familiar with its symptoms.

‘While you are gone, your dog may do one or several of the following: chew
destructively; bark or whine; inappropriate urination and/or defecation; drool;
pace; tremble; vomit – or worse.

‘Separation anxiety is a clinical condition in your dog’s brain. Your pet is
not a bad dog. Your pet’s behaviour is the result of separation
anxiety.’

In Britain, research for Sainsbury’s Bank in 2003 indicated that 632,000 dogs

and cats had suffered from depression in the previous year.

Nearly three times as many had suffered from behavioural problems which could
be linked to depression, such as attacking furniture.

Clare Moyles, Sainsbury’s pet insurance manager, said: ‘People are leading
more stressful lives and unfortunately this can have an adverse effect on the
health of our pets.

‘Cats and dogs can be very susceptible to their owner’s feelings and if they
sense that they are unhappy they can become agitated or depressed.’

Side effects of Reconcile can include lethargy, reduced appetite, vomiting,
shaking, diarrhoea, restlessness, excessive barking, aggression and seizures in
a small number of dogs.

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4/26/2001 – Part 2 – Luvox study on anxiety

http://www.washingtonpost.com/ac2/wp-dyn/A2512-2001Apr25?language=printer

Drug Found to Curb Kids’ Debilitating Social Anxiety

By Shankar Vedantam
Washington Post Staff Writer
Thursday, April 26, 2001; Page A01

Children who are so shy or so attached to their parents that they are afraid
to go to school or sleep alone do much better when given a psychiatric drug,
according to a major study with profound — and controversial —
ramifications for millions of children.

The study of 128 children ages 6 to 17 found that the drug Luvox, widely
prescribed for adults with depression, alleviated the debilitating symptoms
of social phobia, separation anxiety and generalized anxiety — psychiatric
illnesses that afflict as many as 1 in 10 U.S. children.

The effects of the medicine were dramatic, but experts were divided about its
appropriateness: The medicine can help children with severe emotional
problems, but it might also be abused as a chemical quick fix for normal
anxiousness, with lasting effects on growing brains.

“Although the results seem impressive, they nevertheless raise some very
important questions about the use of psychotropic medications in children,”
said Joseph Coyle, chairman of psychiatry at Harvard Medical School, in an
article accompanying the findings in today’s New England Journal of Medicine.

“Any drug that is effective is not going to be innocuous,” he said in an
interview. Children and adolescents diagnosed with these disorders should
first try a form of therapy known as cognitive behavioral therapy, and turn
to medication only if that fails, he said.

An estimated 575,000 children nationwide were diagnosed with anxiety
disorders in the 12 months ending in March, including 136,000 under age 10.
Doctors recommended 390,000 children be put on medicines such as Zoloft,
Paxil and Prozac. Of these, 89,000 were under age 10, according to IMS
Health, a private company that tracks the pharmaceutical industry.

Such vast numbers leave critics aghast. Too many children are being put on
powerful brain-altering drugs for behaviors that may be merely troublesome,
critics say. But other experts point out that many children suffer from
distress that, left untreated, can cause impairment well into adulthood.

“Researchers found that anxiety was among the most common problems that kids
have,” said Daniel Pine of the National Institute of Mental Health. He led
the study. “When researchers follow children with anxiety over time,
sometimes anxiety developed into more chronic problems. It could be the
harbinger of problems with depression, panic attacks and all different kinds
of problems.”

The study, the first large, well-designed survey to examine the effectiveness
of a psychiatric drug for a wide range of anxiety disorders in children, was
partly funded by the National Institute of Mental Health and by Solvay
Pharmaceuticals, which sells Luvox. The drug, which like Prozac increases
levels of the brain chemical serotonin, has been approved for the treatment
of obsessive compulsive disorder in children. Luvox sales were more than $2
billion in the United States last year, according to IMS Health.

Scientists at Johns Hopkins University, Columbia University, New York
University, Duke University and the University of California at Los Angeles
studied the drug over eight weeks in children with anxiety disorders.

An example of a child with severe social phobia would be one who refused to
go to school for two weeks, said Mark Riddle of the Johns Hopkins University
School of Medicine, one of the study’s authors. A milder example, he said,
would be a child who went to school and participated in clubs and group
events, but with intense discomfort.

Extreme separation anxiety disorder, he said, would be displayed in a child
who avoided birthday parties and sleepovers. A medium-grade example would be
children who refused to sleep in their own rooms and wanted to get into bed
with their parents.

Generalized anxiety disorder, Riddle said, were “the worrywarts.”

“A lot of it would be about performance — getting very preoccupied with a
test at school, a lot of fussing about day-to-day things,” he said.

“We don’t want a Prozac nation,” he said about the medication of children.
“We want to make sure we are not doing anything to harm youngsters. On the
other hand, it can be a huge disservice to children to minimize the true
significance of psychiatric impairments that do require treatments. It’s the
latter that can get lost in the very easy and popular position to take, which
is ‘Don’t drug our kids.’ ”

Richard Harding, president-elect of the American Psychiatric Association,
said clinicians should carefully evaluate anxious children to find out
whether their fears are caused by an underlying personality problem — which
would merit psychotherapy or medication — or by a social problem, such as a
bully in school or child abuse at home, in which case medication would be
inappropriate.

“A good clinician will not commit a child to a life sentence on medicine,”
said Riddle. “A good clinician will look to stop medication after the
youngster has had a chance to regroup. You want to work with a clinician who
says we are going to get John off this medication.”

It is unclear what impact this study will have in clinical practice, where
doctors are prescribing children such medicines “off-label” — meaning they
have not been approved for such uses by the Food and Drug Administration.

“Given our current medical-economic system in practice, I suspect both
doctors and parents will be strongly attracted to the quick-fix nature of
this intervention,” said Lawrence Diller, a behavioral pediatrician in Walnut
Creek, Calif., and the author of “Running on Ritalin.”

“We have highly effective psychosocial interventions for these problems,” he
said. But “they are more expensive and take longer.”

He said that helping families come up with parenting strategies could ease
children’s anxieties. “Children are highly responsive to their environments,
and the home is the practice arena to deal with life,” he said. “This is not
parent-blaming — children are difficult to raise. But when the parent makes
changes, you see very rapid changes in the child.”

“It doesn’t negate the value of the medications,” he added. But “with
uncertainty on both sides, effective psychosocial treatments — first do no
harm — take preference.”

More extreme critics, such as Bethesda psychiatrist Peter Breggin, said the
study was produced by scientists who are part of an “old boys’ network of
drug pushers.” He said the psychiatric drugs cause harm — some data have
shown that the drugs cause lasting alterations in the brains of young animals.

Researchers involved in the new study said the drug was well tolerated and
safe.

© 2001 The Washington Post Company

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