9/28/2000 – Learning from Fido’s accidental use of SSRIs

Thanks once again to Robin Eisner for another insightful article about SSRIs.

Warning: Be very careful of your pets around medications and read closely to
see what you might learn from the effects of SSRIs on Fido. This will leave
you asking why these drugs are intentionally given by vets to our pets.

Ann Blake-Tracy
____________

Accidental Antidepression
Dogs Hurt Inadvertently Swallowing Popular People Pills

More dogs these days are unintentionally chomping down their owners’
serotonin-enhancing antidepressants, such as Paxil and Prozac, than they were
five years ago. (Pat Wellenbach/AP Photo)

By Robin Eisner

N E W Y O R K, Sept. 28 Pooches across America are developing a dangerous
drug habit accidental consumption of their owners¹ Prozac-like drugs.
The National Animal Poison Control Center of the American Society for
the Prevention of Cruelty says more dogs these days are chomping down
unintentionally, that is their owners serotonin-enhancing antidepressants,
such as Paxil and Prozac, than they were five years ago.
Dogs are very dogged, explains Dr. Steve Hansen, director of the
Poison
Control Center, which is located in Champaign-Urbana, Ill. They will crush a
bottle of pills with their back molars and lap up the drugs or they will
quickly eat a tablet that an owner inadvertently dropped on the floor.

Established in 1978, the fee-for-service National Animal Poison Control
Center is the only 24-hour emergency telephone hotline staffed by 20
full-time veterinarians and five board-certified veterinary toxicologists in
North America.

Unintended Use

While veterinarians now prescribe antidepressants to dogs to treat canine
sadness, separation anxiety and other behavioral problems, the increasing
problem with unintended ingestion of these drugs by dogs is due, most likely,
to the rising popularity and use of this class of drugs by humans, Hansen
says.

In 1995, 50 percent of the antidepressants accident cases were of the
Prozac type, according to Jill Richardson, a veterinary poison information
specialist at the animal poison center. By 1999, that number jumped to 80
percent of 500 total antidepressant case calls.

The danger antidepressant drugs pose to Fido depends on the amount
wolfed down, the size of the dog and whether the dog had any pre-existing
medical conditions that might make it susceptible to an overdose, Hansen
says.

Danger Depends on Many Factors

Lethargy, vomiting and disorientation are among the symptoms a small dog,
such as a Chihuahua, could experience with a large dose of a Prozac-like
drug. The animal will walk around with its front legs not in sync with its
back legs, looking drunk, Hansen says.
Â
If the owner calls the poison control line before these symptoms develop,
the hotline veterinarians might recommend the owner induce regurgitation with
hydrogen peroxide easily found in most medicine cabinets. The dose with a 3
percent peroxide solution is one milliliter per pound of the dog, which
translates into 2 ounces for a 50-pound dog.

If the dog already is tipsy, however, the vets will probably ask the
owner to take the animal for emergency care, since the animal might need more
specialized treatment. The telephone vets also will suggest an older dog with
kidney disease get to a vet as soon as possible.

Homes Need to Be Pet-Proofed

To prevent an animal from accidental consumption of drugs, owners need to
dog- and cat-proof their house. Medications should be kept in a closed
cabinet beyond their reach, Hansen says. The No. 1 problem drug accidentally
consumed by pets are non-steroidal anti-inflammatory drugs, or medications
like acetaminophen, aspirin or ibuprofen.

While drugs can poison animals, pets also are susceptible to
insecticides, rodenticides and will drink spilled antifreeze and gasoline.
The antifreeze propylene glycol is less toxic to pets than ethylene glycol,
Hansen says.

Cat owners also should not use dog products containing the anti-flea
chemical permethrin on their felines. Owners should not assume because it is
OK for dogs, it is OK for cats, Hansen says. Cats may experience tremors
and seizures from the insecticide.

Why Vet Line Charges?

Pet owners must pay a $45 fee to get assistance from the vets at the
Animal Poison Control Center. The amount covers subsequent calls to the
hotline.

Unlike human poison control centers which are free because they receive
funding from federal, state and local government sources, the animal line
must charge because it only receives partial funding for its operation from
manufacturers of pet care products. The phone number is 1-888-426-4435.

Because large emergency veterinary centers are usually located in large
communities, a pet owner or a veterinarian in a rural community may only have
the hotline to get important toxicological information in a emergency
situation, according to Sharon Granskog, spokeswoman for the American
Veterinary Medical Association, in Schaumberg, Ill. They play a vital
service, she says.

710 total views, 2 views today

Kerri’s Story – My Dark Place on Psychotropic Drugs and ECT

“I had the “electric jitz which feels literally like hot coals inside your back.”

 

An Introduction by Ann Blake-Tracy

I am so concerned at how many I continue to see go through ECT because of reactions they are having to the SSRIs that doctors refuse to see! There is absolutely no need for someone to go through the additional trauma and damage caused by forced seizure activity from an electrical current when what is needed is withdrawal from the offending medication. And why do these doctors remain ignorant of the fact that ECT contraindicated while on SSRI medication due to the risk of the life threatening reaction of “Serotonin Syndrome”? We continue to suffer from an abundance of ignorance about these meds.
———-
I wanted to share my story as a psychiatric drug survivor. I am a college student, I was a senior earlier but this year I had withdraw because of the above problem (i.e. psychiatric drugs) so next year I am to have my senior year.
In August I went to the doctor to refill my anxiety med, Xanax, and because I was concerned with my increasing number of panic attacks. The nurse practitioner refused to give me klonopin (my friend is on that for her anxiety) and instead thrust Paxil at me.

She told me I would “feel crummy for a week” but that after 6-8 weeks it would help my anxiety attacks and it would feel like I wasn’t on anything at all. Stupidly and to my detriment I believed her. I was put on 10 mg. I only lasted 6 days on the stuff! I lost 10 pounds in that period, was dry-heaving and horribly nauseated, I had the “electric jitz” which feels literally like hot coals inside your back (I swear that to God!), palpitations, WORSE anxiety that could not be diminished, I became detached, was unable to concentrate, was crying uncontrollably, had awful stomach gas so tight I couldn’t breathe, had breathing problems, my period lasted 11 days and was heavier than I could ever remember it being, I was constipated, then I had constant diarrhea. Then my thoughts started to race. I went back to the doctor and he just looked at me and asked me why didn’t I just take my Xanax for the anxiety! They told me I was fine, and that it was panic and that I’d be fine. But oh no, fine was the last thing I was. I tried to keep working at my job and had to quit, went back to school and they found me a psychiatrist, who told me that I’d get better and that there were lots of things out there to help me. So he tried me on Celexa.

I was now TERRIFIED of the SSRIs so I didn’t want to, but I tried it for 2 days and stopped it because it made my jitteriness much worse again. So then Dr. H gave me Desipramine. I tried to go to classes, but finally had to withdraw because the meds were making me sicker and sicker and more depressed. I was now down to 84 pounds. This was in early October. My parents took me home to GA, where we found a meds doctor, Dr. W. I slipped farther and farther into the abyss, and then suddenly the Desipramine lifted my mood. It worked like that for ten days, but all the while the racing thoughts were prominent, and my hands kept shaking, and I was well, “high.” Then it kicked out.

So Dr. W upped my dosage (I was at 150 mg) too 200mg, and overdosed me, so I wound up in the hospital because apparently I was threatening to throw myself over the railing of our house or something. (NOTE: not once during the whole ordeal did I ever attempt anything, I merely thought about it).

I saw a Dr. K, there, and he started me on Effexor. This med didn’t work, and it never did anything too bad to my body or mind. Finally, since that wasn’t working, Dr. K put me on this stuff called Risperdal and Depakote. He overdosed me again!! My parents tell me (I have no recollection of this and am thankful to God that I don’t) that I was literally running up and down the stairs because my body couldn’t keep still, the tremors were so bad.

Dr. K wound up going on vacation, and this great doctor, Dr. A. filled in for him. I knew one thing. Dr. A. did ECT. Dr. A. suggested I try Prozac (I was even more terrified after both Paxil, Celexa, and the other meds) but apparently I asked him if I could get ECT done since I knew it was the very last resort and I didn’t really think I’d like to stay like that for the rest of my life. So I got the ECT and within 3 treatments, I was COMPLETELY BACK TO NORMAL. I had all my feelings back, I was ME, I was peppy like usual, I felt terrific! I wish I could remember how it was to wake up that way. My mother told me that I went to sleep and woke up at 4 one afternoon, completely myself again. It was a true miracle. Apparently this is very unusual with ECT because it’s supposed to take many more treatments before you are anywhere near well. After I was done with he ECT the doctors still had me on Prozac.

While I will ill, all I ever said were 3 things: 1) “I’m never going to get better” 2) It’s permanent brain damage” and 3) I want to die. So the idiot doctors diagnosed me as OCD. So I’m fine by February, but all of a sudden my body starts rejecting the Prozac. My vision started blurring out (this was also because of the ECT medication), my anxiety level was rising (I was popping an anxiety pill every 2 days at this point), my limbs were twitching and jumping, I was getting more of that awful stomach gas, and I was starting to get scared. So I made my doctor get me off it and he let me stop it abruptly (since doing that with the other SSRIs is hazardous to your health!!!) and now I am only on 7 mg of Remeron which I am getting off of late this month.

I wanted to sue because of all the losses I suffered this year including: my mental and physical health; my dumping my boyfriend while I was stoned on tranquilizers, the loss of my senior year of college with friends that I have been with for the last 4 years, all the trouble getting reinstated at my college, the nightmares, my fear of even taking ibuprofen for a headache, or even a vitamin, my hatred of psychiatric medicines, therapists, and the drug companies, my fear of going back to that dark place, all that lost time!!!! But I can’t sue because I’m not in the mood to wait a few years for any decision.

So I am just going to file with the FDA. Thank you for reading this, if I sent this wrong, please post it up on this site for me.

God bless you for your intelligence on these matters.

Kerri

 

Years 2000 and Prior

This is Survivor Story number 50.
Total number of stories in current database is 96

 

273 total views, 2 views today

6/22/2000 – Antidepressant Controversy

A revealing chat transcript with Dr. Joseph Glenmullen regarding
SSRI’s and suicide can now be found on the ABCNews.com.
Link follows the introduction.
————–

Antidepressant Controversy
Chat with Dr. Joseph Glenmullen

June 21
Dr. Joseph Glenmullen
Experts agree that drugs like Prozac and Zoloft (known medically
as Selective Serotonin Reuptake Inhibitors or SSRIs) are
effective, beneficial and crucial to patients who suffer severe
depression.

But is it possible that they may actually have a negative effect on
certain patients, possibly even driving some to suicide?
Dr. Joseph Glenmullen, author of Backlash: Overcoming the
Dangers of Prozac, Zoloft, Paxil, and Other Antidepressants with
Safe, Effective Alternatives joined us online in a chat immediately
following the broadcast.

For a transcript of this chat, please go to
http://abcnews.go.com/onair/2020/000621_prozac_chat.html

594 total views, 2 views today

5/24/2000 – Salon Magazine addresses the SSRIs

Salon Magazine has put several articles out this week on the SSRIs. The first
article is about Dr. Joseph Glenmullen’s new book “Prozac Backlash.” Of
course in their usual form Eli Lilly representatives and other critics have
slammed it as misleading and lacking in scientific rigor. And now the author
claims Eli Lilly reps are harassing him. After ten years of writing about
these drugs learning this is no surprise me at all. I extend a hearty welcome
to Dr. Glenmullen as he joins the group of us who are all too familiar with
that type of harrassment from Lilly. 🙂 The article is Prozac Indignation –
How a little-known Harvard clinician needled sleeping giant Eli Lilly.

http://www.salon.com/health/feature/2000/05/17/backlash/index.html?CP=SAL&DN=1
10

A second piece looks at the sexual side effects of the drug. And the third is
an essay by a woman who has taken the pills for 13 years and calls them her
salvation. “She addresses the school of thought that says happiness shouldn’t
be come by quite so easily.”

I have really reached a saturation point on the “happiness shouldn’t be come
by quite so easily” comments. I would like to point out that no amount of
“happiness” (drug-induced high) is worth what even one of the families who
have lost a loved one to these drugs has had to suffer! The price for that
“happiness” has NOT come easily. In reality the price has been far too great
for far too many! When there are so many safe, natural alternatives to reach
a true feeling of happiness, there is absolutely no excuse to cause such pain
and suffering for so many others in order for even one to achieve this
drug-induced high. The risk vs benefit ratio is much to great to justify the
use of these drugs.

Ann Blake-Tracy, Executive Director,
International Coalition For Drug Awareness
www.drugawareness.org

636 total views, 1 views today

5/16/2000 – Long-Term Side Effects Surface With SSRIs

The following are excerpts from Clinical Psychiatry News about long-term
adverse effects of SSRIs. They could have learned this YEARS earlier by
reading my book, Prozac: Panacea or Pandora? but at least they are FINALLY
talking about it and as many of you have asked, I thought you would want this
reference.

Ann Blake-Tracy, Executive Director,
International Coalition For Drug Awareness

From Clinical Psychiatry News

Long-Term Side Effects Surface With SSRIs

Author: Carl Sherman, Contributing Writer
[Clinical Psychiatry News 26(5):1, 1998. © 1998 International Medical News
Group.]

——————————————————————————

Insomnia, weight gain, sexual dysfunction emerge as problems affecting
compliance.

NEW YORK — Physicians are seeing long-term side effects with selective
serotonin reuptake inhibitors far in excess of what was expected from
clinical trial data, Dr. Norman Sussman said at a psychopharmacology update
sponsored by New York University.

If these particular side effects — sleep disturbances, sexual dysfunction,
and weight gain — are problematic for patients, one of the newer non-SSRI
antidepressants may be a better choice, he said. Of course, these drugs have
their own particular side effect profiles.

When SSRIs first appeared a decade ago, their favorable side effect profile
was a key selling point. They were clearly safer and easier to use than
tricyclics and monoamine oxidase inhibitors and, above all, better tolerated
by patients.

But experience has shown that some side effects are more common and
problematic than initially expected, said Dr. Sussman, director of the
psychopharmacology research and consultation service at Bellevue Hospital
Center in New York. . . . adverse effects that persist as long as the patient
takes the medication, such as sexual dysfunction and sleep disturbances. Also
particularly troubling are those, like weight gain, that don’t even develop
until late in treatment. “These are the ones that are not in the insert,
which is based on short-term studies,” Dr. Sussman said.

Significant insomnia affects 15%-20% of patients taking SSRIs, twice the rate
with placebo. Polysomnography has consistently found that these drugs cause
activation during the night: In addition to insomnia, bruxism, sweating, and
periodic limb movement are common. Vivid dreams and nightmares also occur.
With ongoing treatment, increasing numbers of patients report lethargy and
fatigue, he said.

“There are a lot of data showing that people who sleep poorly are more likely
to relapse and that suicide risk is higher,” he said. . . .

Sexual dysfunctions are among the most distressing SSRI side effects.
Decreased libido and delayed or absent orgasm are the best known, but there
are others, such as the “yawning-excitement syndrome.” Patients experience
sexual arousal when they yawn, often progressing to orgasm. “This is probably
underreported. Patients often say, ‘If you hadn’t asked me, I wouldn’t have
mentioned it,'” he said.

Perhaps the most unexpected SSRI-related problem to emerge has been weight
gain, which often begins only after several months of therapy. This side
effect has not been shown to be frequent or severe in controlled studies but
has been reported to occur in 18%-50% of patients in some open-label studies.

Because this runs counter to the image of the drug, many physicians and
patients are unprepared to deal with it. “Some physicians tell patients, ‘I
can’t understand why you’re gaining weight — you’re on an SSRI,'” Dr.
Sussman said.

Greg Keuterman, a spokesman for Eli Lilly & Co., manufacturer of Prozac
(fluoxetine), declined to comment except to point out that “this is anecdotal
evidence.”

“We’re approved by the FDA for long-term treatment of depression,” he added.

Pfizer Inc., the maker of Zoloft (sertraline), and SmithKline Beecham
Pharmaceuticals, the maker of Paxil (paroxetine), did not respond to requests
for comment.

These observations do contrast with what the clinical trials submitted to the
Food and Drug Administration by pharmaceutical companies show, Dr. Sussman
said. It would be nice if these long-term side effects were studied in
clinical trials comparing different antidepressants. . . .

792 total views, 3 views today

The Aftermath of Antidepressants

The Aftermath Of Prozac, Zoloft, Luvox, Fen-Phen, & Many Other Serotonergic Drugs

By Ann Blake-Tracy – Executive Director,
International Coalition For Drug Awareness

Ann Blake-Tracy has specialized for 10 years in adverse reactions to serotonergic medications. She is the executive director of the International Coalition for Drug Awareness (www.drugawareness.org) and author of the book PROZAC:PANACEA OR PANDORA?

WARNING: IT SHOULD BE NOTED THAT A GRADUAL TAPERING OFF OF MEDICATIONS IS SAFEST WITHDRAWAL METHOD TO AVOID SERIOUS WITHDRAWAL EFFECTS

Often there is the terrible withdrawal associated with the SSRIs. Unless patients are warned to come very slowly off these drugs by shaving minuscule amounts off their pills each day, as opposed to cutting them in half or taking a pill every other day, they can go into terrible withdrawal which is generally delayed several months. This withdrawal includes bouts of overwhelming depression, terrible insomnia and fatigue, and can include life-threatening physical effects, psychosis, or violent outbursts.

Note: Keep in mind that these drugs are all serotonergic agents and clones or “copy cat” drugs of Prozac – the first SSRI antidepressant introduced to the market in America. Basically what applies to one, applies to the others. For instance we have more data out on Prozac because it has been around longer, but as the mode of action is the same for all of these meds the effects will be the same for the other drugs on this list as it is for Prozac. If we are discussing one drug, similar effects would be expected from any other company’s version of the drug. In fact it would be more honest to give them the titles of Prozac #1, Prozac #2,Prozac #3, etc. rather than the brand names they have been given, from the second clone, Zoloft, to the latest Prozac clone, Celexa.

My concern is that each new SSRI introduced seems to be a little stronger on serotonin reuptake and therefore potentially more dangerous. And the all too common practice of going from one SSRI to another blocks additional receptors and magnifies the harmful effects of these medications. It is crucial to learn that according to medical research the theory behind this group of drugs is invalid. Known as serotonin reuptake inhibitors. They are designed to block serotonin in the brain, thereby increasing brain levels of this neurotransmitter. Yet for three decades researchers have been intensely interested in serotonin because LSD and PCP produce their psychedelic effects by mimicking serotonin. Elevated serotonin is found in: psychosis or schizophrenia, mood disorders, organic brain disease, mental retardation, autism and Alzheimer’s. While low levels of the metabolism of serotonin (which also produces high serotonin), are found in those with: depression, anxiety, suicide, violence, arson, substance abuse, insomnia, violent nightmares, impulsive behavior, reckless driving, exhibitionism, hostility, argumentative behavior, etc. The drugs increase serotonin and decrease the metabolism of serotonin leading to any and all of the above results. This information is extremely crucial for patients and physicians to learn as soon as possible. We have a high rate of use of these drugs nationwide. Raising serotonin and lowering the metabolism of serotonin in such a large number of people can produce very serious, widespread and long term problems for all of society.

So why are we now in the 90’s being told that increased serotonin is good for us? Is it because it is good for the pocketbooks of the manufacturers? One manufacturer is running full page newspaper and magazine ads and half hour TV infomercials to bring in over $7 million daily, while on the other hand they are settling Prozac suicide cases for huge amounts of money in exchange for silence from victim’s families on the details of those settlements. The silence in the court cases insures that the drug will be allowed to finish out its patent time, thus bringing in the highest possible profits for the company. They know that with $7 million coming in daily, they can afford to settle a large number of lawsuits and still come out “smelling like a rose” financially.

Eli Lilly has been sued for Prozac related deaths in numerous state and federal courts with most of these cases being settled or dismissed – many were dismissed due to the unethical manipulation of the Wesbecker verdict
(see time line for details).

We have witnessed no decrease in suicide, but increases in murder/suicide, suicide, unwed pregnancies, domestic violence, manic-depression, MS, hypoglycemia, diabetes, bankruptcies, divorce, mothers (parents) killing children, road rage, school shootings, cancer, Chronic Fatigue Syndrome, and Fibromyalgia since these serotonergic drugs have become so popular and I relate it directly to the effects of these drugs.

The death toll has continued to climb drastically since I wrote PROZAC: PANACEA OR PANDORA? Some of the cases you may be familiar with are:

1. Mr. and Mrs. Phil Hartman (Zoloft), Prozac was found in the van of Mark Barton, the Atlanta day trader, who recently killed his family and others in a shooting spree before taking his own life;
2. Neal Furrow, in LA Jewish school shooting was reported to have been court ordered to be on Prozac along with several other medications;
3. The Salt Lake Family History Library shooting;
4. School shootings in Littleton, Colorado (Luvox), Atlanta, Georgia, Springfield, Oregon (Prozac), and Caldwell, Idaho;
5. Another boy in Pocatello, ID in 1998 who in seizure activity from Zoloft had a stand off at the school;
6. 15 year old Chris Shanahan (Paxil) in Rigby, ID who out of the blue killed a woman;
7. The shooting at the lottery in Connecticut last spring by Matthew Beck (Luvox) that left five dead in a murder/suicide;
8. The New York City Subway bombing by Edward Leary (Prozac);
9. Nick Mansies (Paxil) in New Jersey who was convicted of killing a little boy who was selling cookies door to door;
10. In Orange County, CA Dana Sue Gray (Paxil) who co-workers described as a very caring nurse killed several elderly people;
11. Officer Stephen Christian (Prozac) one of the finest officers on the Dallas Police force, who ran into a police substation shooting at fellow officers and was killed;
12. 13 year old Chris Fetters (Prozac) in Iowa who killed her favorite aunt;
13. David Rothman (Prozac) killed two co-workers and himself at the Dept. of Agriculture in Ingelwood, CA;
14. Williams Evans (Zoloft) shot one co-worker at the Ohio Bureau of Employment Services before shooting himself in Columbus, OH;
15. Winatchee, WA where 43 people were wrongfully imprisoned in a false accusation of sexual abuse “witch hunt” fury started by a child under the influence of Prozac and Paxil;
16. Christopher Vasquez (Zoloft) killed Michael Morrow in Central Park;
17. Megan Hogg (Prozac) duct taped the mouths and noses of her three little girls and took a handful of pills; Vera Espinoza (Prozac) in Randolph, VT shot her small son and daughter before shooting herself;
18. An elderly man (Prozac) in Layton, UT axed his wife and daughter to death;
19. Margaret Kastanis (Prozac) used a knife and hammer to kill her three children before stabbing herself to death;
20. An elderly man (Paxil) in Dallas, TX strangled his wife before shooting himself twice in the chest;
21. Larramie Huntzinger (Zoloft) blacked out and ran his car into three young girls killing two in Salt Lake City, UT;
22. Mary Hinkelman (Prozac), a nurse in Baroda, MI shot her two small daughters and her sister before shooting herself;
23. Lisa Fox (Prozac) shot her small son and her dog before shooting herself in Brighton, MI;
24. Debi Louselle (Zoloft) shot daughter and then herself in Salt Lake City, UT;
25. A father in Wyoming shot his wife, daughter and baby grand-daughter then himself after only days on Paxil;
26. A mother (Prozac) in Pleasant Grove, UT killed her 17 year old son with a sledge hammer while he slept before she attempted suicide by drinking Drano;
27. Larry Butz, a superintendent of schools in Ames, IA shot his wife, son and daughter before shooting himself – many cases pending in court are not mentioned.

This is only a handful of MANY, MANY more cases – there would not be room for anything else if I continued listing the cases.

A few additional famous victims: Princess Di (Prozac) and Dodi Fayed -via their driver Henri Paul (Prozac), Monica Lewinsky (Prozac, Zoloft, Effexor, Serzone and Phen-Fen), Chris Farley (Prozac), Pres. Clinton’s ex-partner Jim Mc Dougal (Prozac), Abby Hoffman (Prozac), Del Shannon (Prozac), Danielle Steele’s son (Prozac), INXS singer Michael Hutchence (Prozac), Sarah – Dutchess of York (Phen-Fen)

The latest figures show Prozac has about 44,000 adverse reports filed with the FDA. Out of those reports there are about 2,500 deaths with the large majority of them linked to suicide or violence.

The suicide statistics relating to women are shocking. According to the CDC there are about 30,000 suicides yearly in the United States. Out of those about 6,000 are women – a ratio of about 4.3 to 1, male to female. About twice as many women as men are treated for depression demonstrating that generally men are more than 8 times as lethal in their suicidal gestures as women. Women were known to use less lethal means until the SSRI antidepressants hit the market. But on Prozac and Paxil, women committed 40% of the suicides – many were strikingly violent and clearly leaving no
means for rescue. (Remember that because Prozac was the first of this group of drugs its track record gives us a vision of what is to come with other serotonergic antidepressants, especially when they are so powerful in the reuptake of serotonin.)

TIME LINE OF CRITICAL INFORMATION DISCOVERED SINCE THE BOOK:

*NOTE: Any documents beginning with PZ are Lilly documents on Prozac which have been ferreted out by attorneys and are now being used in lawsuits against the drug company. (Christian vs. Eli Lilly, by Vickery & Waldner, Houston, TX)

* Mid 1950’s: Dr. Felix Sulman began his research on those who suffer from high serotonin levels because of an inability to metabolize serotonin. He found that serotonin is a stress neuro-hormone leading even rabbits, the most docile of creatures, to be aggressive. He coined the term “serotonin irritation syndrome.” He found that those who were unable to break down serotonin would have the levels increase. They were in effect being poisoned by the serotonin produced by their own bodies, the irritation victims suffered from migraines, hot flashes, irritability, sleeplessness, pains around the heart, difficulty in breathing, a worsening of bronchial complaints, irrational tension and anxiety. . . horrifying nightmares. It also caused his volunteers to sleep badly – that is, always on the edge of consciousness so that they were not properly rested – and to wake after only a few hours of sleep.” (sleep apnea) He also found it caused pregnant women to abort.
* October, 1977: Slater, et.al., Inhibition of REM Sleep by Fluoxetine, a Specific Inhibitor of Serotonin Uptake, October 1977, at p. 385 – Prozac was found to affect sleep habits, specifically to suppress deep sleep, which the scientists call REM (rapid eye movement) sleep in cats. By the fourth day of drug treatment the cats receiving the larger doses, which had been friendly for years, began to growl and hiss. After cessation of the drug treatment, the cats returned to their usual friendly behavior in a week or two; those on the higher doses recovering more slowly. – – 1977: [PZ 1298 1999] “A total of six dogs from the high dose group were removed from treatment … due to severe occurrences of either aggressive behavior, ataxia, or anorexia.”]
* July 31, 1978: [PZ1061 1025-28, July 31, 1978] Human subjects began to be used by Lilly in controlled clinical trials. The first group of patients showed no improvement in their depression, but there were a “large number of reports of adverse reactions.” The first human to receive Prozac experienced “dystonia resembling an extrapyramidal reaction” – an uncontrollable, Parkinson-like shaking or trembling.
* July 23, 1979 [PZ 1297 969] The clinical studies in depression showed that “some patients have converted from severe depression to agitation within a few days; in one case the agitation was marked and the patient had to be taken off drug. In future studies the use of benzodiazepines to control the agitation will be permitted.”
* August 3, 1979: The clinical trials excluded patients who had serious suicidal risk. [E.g. control #001519, IND Protocol No. 14, August 3, 1979; PZ1135 695, July 2, 1986 memorandum of Dr. Wernicke].
* December 17, 1984: [PZ 65 449, report of Lilly to FDA] Lilly reported to the FDA that benzodiazepines and other sedatives were given with Prozac throughout the clinical trials. This was to help offset the stimulant effect of the drug. In a memorandum of Lilly scientist Charles Beasley [PZ 541 2007-08] issues of “agitation vs. sedation” and concomitant sedative medications like benzodiazepines (to control the agitation) are discussed. Concerns are that agitation in a suicidal patient can induce suicide.
* March 3, 1986 Lilly controlled the flow of information to the FDA and decided that suicide data on Prozac should not be evaluated, “in the safety-update for the FDA the number of suicides and suicide attempts will not be especially evaluated.” [PZ 879 1966, March 3, 1986 telex]
* September 12, 1986: German BGA very concerned with the risk of suicide and ultimately approved Prozac on the condition that physicians be warned of the risk of suicide and told to consider using sedatives and closely monitor patients. [PZ 878 1383, report of Lilly consultant Pohlmeier; PZ 2467 299, September 12, 1986] Lilly actually warned physicians in Germany and other countries that this measure “can be necessary” to minimize the risk of suicide, [PZ 1341 402, December 6, 1989 German warning; PZ 2469 490]
* February 7, 1990: In response to the Harvard study, Teicher, et al., Lilly’s top scientist, Leigh Thompson, told his fellow executives that “Lilly can go down the tubes if we lose Prozac”. [PZ 1941 827, February 7, 1990]. In the ensuing months Dr. Thompson spoke frequently with his principal FDA regulator about the issue, once at 6:15 in the morning. [PZ 391 1959, July 18, 1990]. Lilly later described the man as “our defender”. [PZ1941 2256, September 12, 1990]
* May 29, 1990, Lilly added “suicidal ideation” in the section dealing with post-marketing reports. [PZ883 562, July 26, 1990 memorandum]
* September 14, 1990: Contrary to the advice of his staff, Dr. Thompson told the Eli Lilly Board of Directors that suicide and hostile acts were probably, caused by the patients’ underlying disorders rather than Prozac. [PZ542 2101, September 14, 1990; PZ4002 889, Board Minutes]. The staff was concerned because they knew that this issue was never studied during the clinical trials.
* September 11, 1990: Note from Dr. Bruce Stadel, Chief of the Epidemiology Branch, attaching an analysis done by Dr. David Graham, Section Chief within the Epidemiology Branch, of Lilly’s July 17, 1990 submission to the FDA on the Prozac/suicidality/violence issue. The following factors were (a) brought to the attention of those in the higher echelons of the FDA, but (b) ignored, discounted or “trashed” by them: #1 Lilly’s analysis improperly excluded 76 out of 97 suicides; as Dr. Stadel expressed it, “[i]t is inappropriate in a safety analysis to exclude such a large proportion of case”; #2 Lilly admitted that its clinical trials “were not designed for the prospective evaluation of suicidality” and that “[i]n these trials, patients with current suicidal ideation were excluded”; #3 Lilly admitted that the HAMD-3 rating scale it used to assess suicidality in clinical trials was inadequate; and that Lilly’s statements about violence only demonstrated “how great under-reporting is” and that “[t]he actual data showed a higher percentage of treatment-emergent suicidality among fluoxetine (2.9% than tricyclic (0.8%) patients . . . [which percentage] was similar to that reported by Teicher.”
* July 1, 1992: A study lead by Dr. Lorne Brandes of the Manatoba Institute of Cell Biology in Winnipeg, Canada was published in CANCER RESEARCH linking the two most popular anti-depressants, Elavil and Prozac to cancer.
* 1994: A study headed by Howard Markell published in The Journal of Pediatrics showed LSD flashbacks and LSD reactions induced by Prozac.
* June 9, 1994: The New York Review of Books article by Dr. Sherwin Nuland slams Peter Kramer for pushing Prozac in his book Listening to Prozac. He pointed out that all docs are taught in med school this little poem about serotonin: “This man was addicted to moanin’, confusion, edema, and groanin’, intestinal rushes, great tricolored blushes, and died from too much serotonin.” He listed constriction of lungs and intestines, diarrhea, wheezing, flushing, mental confusion, tightening of bronchioles, and lessening conscious control over behavior from increases in serotonin. “Moreover, . . . it is still too early to arrive at a reliable estimate of possible dangers that may appear in the long term,” and 15% dropped out of the clinical trials on Prozac because of adverse reactions. He also discussed the similarity of serotonin to the psychedelics like LSD and PCP.
* November, 1994: Krystal JH, Webb E, Cooney N, et al., “Specificity of Ethanol-like Effects Elicited in Serotonergic and Noradrenergic Mechanisms,” ARCHIVES OF GENERAL PSYCHIATRY, Vol. 51, Issue 11, pgs 898-911, 1994 demonstrated that an increase in brain levels of either of two neurotransmitters, serotonin or noradrenalin, produces:
#1 a craving for alcohol,
#2 anger,
#3 anxiety.
They found this to be especially true for those who have a history of alcoholism. An increase serotonin in turn increases noradrenalin. Numerous reports have been made by reformed alcoholics who are being “driven” to alcohol again after being prescribed a serotonergic drug. And many other patients who had no previous history of alcoholism have continued to report an “overwhelming compulsion” to drink while using these drugs.

A few personal accounts:

#1 A young woman, a recovering alcoholic, reported that during the eight month period she had been using Prozac she found it necessary to attend AA meetings every day in order to fight off the strong compulsions to begin drinking again.
#2 In the Southeastern United States a middle aged psychologist, also a recovering alcoholic, after being prescribed Prozac, found herself needing to attend AA meetings morning, noon, and night to keep from destroying the sobriety she had achieved.
#3 A young father, who was Mormon and had never before in his life used alcohol, found himself drinking Ever Clear and exhibiting bizarre as well as violent behavior, after being prescribed Prozac and Ritalin.
#4 A young mother who had never used alcohol before began drinking large amounts within weeks of being prescribed Prozac and quickly found herself committed to a mental institution due to the psychotic behavior that resulted. Added to her Prozac prescription were anti-psychotic meds and electric shock treatments. She then began to experience seizures and was started on anti-seizure meds.
#5 A concerned neighbor reported her friend was drinking straight Vodka on a regular basis after being prescribed Zoloft. #6 A daughter reported her father, sober for 15 years, began drinking again on Prozac.

* December, 1994: Not guilty verdict on Wesbecker wrongful death suit against Lilly’s Prozac.
* Treatment emergent suicidality with Prozac has been demonstrated to be two to three times higher than any other anti-depressant. (Jick, et al., Antidepressants and Suicide)
* May, 1995: Judge John Potter who presided over the Wesbecker case filed documents to demand that Lilly be forced to disclose the secret deal they made with the plaintiffs to withhold very damaging evidence in exchange for settlement. In his pleading to the court Potter stated, “Lilly sought to buy not just the verdict, but the court’s judgment as well.” Potter accused Lilly of “giving the verdict the widest possible publicity” accompanied by the claim that Lilly had “proven in a court of law that Prozac was safe.” Furious with Lilly’s attempt to turn his courtroom into an advertising agency for Prozac, he claims his motion reflects “the court’s duty to protect the integrity of the judicial system.” He believes, as do prominent legal ethicists, that a full and open disclosure of the terms of the settlement is a necessary public safety issue.
* July, 1997: Mayo Clinic found that the increased serotonin, which produces blood clotting, was causing a gummy glossy substance to build up on heart valves. Dr. Heidi Connolly with the Divisions of Cardiovascular Diseases and Internal Medicine, who headed the study stated, “We do know that fenfluramine and phentermine [Fen-Phen] alter the way the brain chemical serotonin is metabolized, and serotonin that circulates in the blood can cause valve injury.” Fenfluramine produces a rapid release of serotonin, inhibits serotonin reuptake, and may also have receptor agonist activity. The study’s revelations should send a loud and very clear warning throughout the medical community concerning all serotonergic medications.
* August 25, 1997: Letter to Ann Blake-Tracy, “I caught the last part of your presentation on Radio Station KEX, Portland, while flipping through the dial last night. I was flabbergasted to hear you speak of the horrible potential side effects from Prozac, which I have been taking for approximately four years, particularly since I have been diagnosed recently with cardiomyalgia, severe artery disease, congestive heart failure and also Fibromyalgia. (I was a very “well” person prior to taking the Prozac and am now exhausted all the time, with horrible aching joints and considerable pain and a massive heart problem.) The adverse cardiovascular effects from Prozac, the one drug in this class of drugs out long enough to have somewhat of track record, are listed in the drug information sheet put out by the manufacturer. The “frequent” effects listed are hemorrhage and hypertension. The “infrequent” effects include very serious adverse effects: congestive heart failure, myocardial infarct, tachycardia, angina pectoris, arrhythmia, hypotension, migraine syncope and vascular headache.
* September, 1997: Redux and Phen-Fen were pulled from the market.
* October 20, 1997: Dr. Candace Pert, Research Professor at Georgetown University Medical Center, past head of the brain chemistry department at the National Institute of Health, and author of the new book, MOLECULES OF EMOTION, sounded an alarm in TIME, October 20. She stated, “I am alarmed at the monster that Johns Hopkins neuroscientist Solomon Snyder and I created when we discovered the simple binding assay for drug receptors 25 years ago. Prozac and other antidepressant serotonin-receptor-active compounds may also cause cardiovascular problems in some susceptible people after long-term use, which has become common practice despite the lack of safety studies.”
As we are being led to believe these drugs produce effects only in the brain, Dr. Pert accuses the medical profession of oversimplifying the action of these drugs and adds that “the public is being misinformed about the precision of these selective serotonin-uptake inhibitors.” It is critical that both physicians and patients be made aware of these adverse physical reactions. She points out that the medical profession not only oversimplifies the action of these drugs in the brain, but “ignores the body as if it exists merely to carry the head around!” And that, “these molecules of emotion regulate every aspect of our physiology.” The body plays a very significant role in how we feel and act the way we do. This fact can no longer be ignored. Serotonin and serotonin receptors exist throughout the body, as well as the brain, and every aspect of the body’s physiology is affected by these serotonergic medications. In fact approximately 90% of the body’s serotonin is produced in the intestinal tract. According to Dr. Michael Gershon of New York’s Columbia Presbyterian, this is the reason why Prozac produces so many gastrointestinal side effects.
* March, 1998: Two new studies published. One that shows Prozac so strongly inhibits one particular serotonin receptor that this produces both obesity and seizures and the other discusses the blockage of muscle and neuronal nicotinic acetylcholine receptors indicating interactions between the serotonergic and cholinergic systems in the central nervous system.
* April, 1998: Our next generation of guinea pigs – one month before a 15 year old on Prozac, Kip Kinkel, in Springfield OR killed his parents and two classmates the American Psychiatric Association and the American Academy of Pediatric Psychiatrists asked the FDA to consider the serotonergic antidepressants for use in children as young as two and drugs for anxiety, aggression and manic depression in babies only one month old! The use of Prozac among young children ages 6 – 12 has increased an alarming 400% from 1995 (51.000 new prescriptions) to 1996 (203,000 new prescriptions).
* June, 1999: CLINICAL PSYCHIATRY NEWS reported that Dr. Malcolm Bowers a psychiatrist at Yale has found that physicians are not paying enough attention to patient factors that could make initiation of SSRIs dangerous. He found that “SSRI-induced psychosis has accounted for 8% of all general hospital psychiatric admissions over a recent 14-month period.” And “What is surprising is that this particular group of side effects is really underplayed.” (The 8% figure represents over 150,000 SSRI induced psychotic breaks per year!!!!!!!)

WARNING: Children so often get coughs and colds, yet using a cough or cold medication with dextromethorphan could cause the serotonin syndrome, a very serious and potentially fatal adverse reaction and/or produce PCP reactions.

Serotonin syndrome remains an often misdiagnosed or unrecognized fatal reaction due to the medical profession being so uninformed about this drug-induced disorder.

Developing brains are far more vulnerable than adult brains and brain damage generally becomes more apparent after the brain is fully developed, rather than immediately. Increases in cortisol produce brain damage while medical research shows that one single 30mg dose of Prozac DOUBLES the level of cortisol. This drastic increase in cortisol causes a multitude of serious physical reactions including impairment of linear growth, as well as impairing the development and regeneration of the liver, kidneys, muscles, etc. In light of so many unspeakable tragedies, I have grown weary of all the silly philosophical discussions we have heard since Kramer’s LISTENING TO PROZAC came out. Patients are dying or having their health destroyed mentally as well as physically (when do we begin to discuss the very serious physical side effects associated with high levels of serotonin?). These patients and their families are frantically searching for answers while this research sits right under our noses and could easily be made available to them. The widespread use of Prozac and its clones is not a statement of either their safety or their effectiveness. It is a statement about the effectiveness of an infinite marketing budget and incredible advertising campaign! These drugs have very serious physical side effects, as well as dangerous psychiatric side effects.

To prevent further tragedy this medical research must be acknowledged and addressed in headline news without delay rather than remain buried in seldom read medical research documents as has been the case in the past with other mind- altering medications, once thought to be safe, which were subsequently prohibited by law, i.e. LSD, PCP, cocaine, etc.

PRAISE FOR PROZAC: PANACEA OR PANDORA?

“I started having bad reactions . . . Oct ’96 I found Prozac to be causing joint and muscle pain itself . . . signs of Cushing’s Syndrome. . . I was very pro-Prozac until last October and wouldn’t have listened to anything said against it until I got problems (thought it was saving my life, while all the time it was insidiously and interested but quite skeptical. However, since reading it and having suffered so many problems with Prozac, I have come to the conclusion that the book is brilliant, and a life-line as far as I am concerned. I tried to fault the research and reasoning, but could not and still can’t. I would like to extend my thanks to you for your heroic stance on this enormously important issue. I have tremendous respect and admiration for your hard work, determination and courage in pursuing this subject so vigorously, against so much powerful opposition for the benefit of people like me. Your integrity puts many, if not most doctors and psychiatrists to shame. It is reassuring to find that there are a few people who are prepared to fight for the truth for the benefit of mankind.” Oct. 1998 note from a British nurse

“PROZAC: PANACEA OR PANDORA? is an incredible compilation of medical data that will lay the groundwork to educate other professionals and the general public about the new SSRI antidepressants – Prozac, Zoloft, Paxil, Luvox, Effexor and Serzone.” (Jeff Wise, psychologist, Salt Lake County Drug and Alcohol Abuse )

“In 15 years of reading books on drugs I have never read a book with more information or so well documented as PROZAC: PANACEA OR PANDORA?” (Dr. Kevin Millet, Bountiful, UT)

“As I lecture to physicians nationwide on the medical use of psychoactive drugs PROZAC: PANACEA OR PANDORA? always accompanies me in my brief case.” (Dr. Bruce Woolley, neuropsychopharmacologist, Brigham Young University)

“I found PROZAC: PANACEA OR PANDORA? fascinating reading and the most complete analysis of the various factors pertaining to the Prozac controversy.” (Attorney Donald Sokol, Susanville, CA)

“PROZAC: PANACEA OR PANDORA? literally saved my life, and if I’d known about it a year earlier, could have saved me untold grief and agony as well. It is the only collated, comprehensive source I know of for this information , . . .. this book described everything that had happened to me in great detail, gave scientific reasons why it happened, backed it all up with solid research, included testimonials from hundreds of others in the same situation, it immaculately details, explains, and refers one to the latest research on a whole hornet’s nest of ‘atypical’ side-and/or after-effects from the use of these antidepressants. It also contains information on how to reduce the severity of problems encountered while starting on or going off these meds.” (Nick Jameson, Prozac patient)

“Magnificent! This text is a monument to Ann Tracy’s tenacity and love for her fellow human beings.” (Dr. Paul Kennedy, N.J.)

“PROZAC: PANACEA OR PANDORA? has not left one question about these drugs unanswered! Ann Tracy has covered them all.” (Margaret McCaffery, N.Y. who lost her daughter, a neurosurgeon, in a Prozac suicide)

“The work Ann Blake-Tracy is doing is very important and she is truly a heroine.” (Dr. Candace Pert, Washington, DC, one of the two developers of the serotonin binding process which made possible the development of the serotonergic drugs. Dr. Pert has boldly stated, speaking of these serotonergic medications, “I am alarmed at the monsters I created!”)

WARNING: In sharing this information about adverse reactions to antidepressants I always recommend that you also give reference to my CD on safe withdrawal, Help! I Can’t Get Off My Antidepressant!, so that we do not have more people dropping off these drugs too quickly – a move which I have warned from the beginning can be even more dangerous than staying on the drugs!

The FDA also now warns that any abrupt change in dose of an antidepressant can produce suicide, hostility or psychosis. And these reactions can either come on very rapidly or even be delayed for months depending upon the adverse effects upon sleep patterns when the withdrawal is rapid! You can find the CD on safe and effective withdrawal helps here: http://store.drugawareness.org/

Learn More
http://www.drugawareness.org/wp-content/uploads/wpsc/product_images/thumbnails/helpicant.jpg
Order Today

 

2,579 total views, 2 views today

09/16/1999 – ABC News Transcript 9/15/99–SSRI Effectiveness

Thanks to one of our ICFDA Directors for obtaining the following for us:

The following message is a transcript of last night’s ABC News with
Peter Jennings: a message about the SSRIs. Tonight Peter Jennings will
discuss the “side-effects” of the SSRIs.
———————————————————————–
Peter Jennings ABC News: September 15, 1999

Peter Jennings: “Just when is the drug actually making a difference?
Antidepressants are very popular these days: sales are up 17% from just
last year. Millions and millions of prescriptions now are being
written to
battle depression and mood swings. Tonight, are these drugs really
doing
everything that people think they are? Here’s ABC’s Deborah Amos ”

Deborah Amos: “These depression fighting pills are 60 – 70% effective in
bringing relief according to the medical literature. But Thomas Moore,
who
studies drugs at George Washington University, says the numbers are
misleading”

Thomas Moore: “Millions of Americans believe that the benefits of these
drugs are much greater than they are”

Deborah Amos: “To investigate, Moore analyzed all drug company tests on
five major drugs submitted to the FDA prior to market approval: for
Paxil,
Zoloft, Effexor, Serzone and Prozac. The effectiveness of the drug was
measured against a placebo or sugar pill.”

Thomas Moore: “The effect of antidepressants drugs on depression is
only
very little different than the effect of a completely inactive placebo.”

Deborah Amos: “The highlight of Moore’s finding is the case of Prozac
with
more than $2 billion dollars in U.S. Sales. About 90% of Prozac’s
overall
effectiveness is about the same as patients taking nothing stronger
than a
sugar pill. But the label for antidepressant drugs, the prescribing
detail
for doctors, usually do not spell out the small overall differences
between
the drug and the placebos.”

Thomas Moore: “At the very least the FDA product labeling should
include a
more balanced picture of all the information they have received about
the
drug, – about all the clinical trials.”

Deborah Amos: “”The FDA says it does not put that kind of detail on the
label because it is not helpful in predicting individual outcomes. So
what
does it all mean for patients, when a placebo can have almost the same
benefits as a dug, and particularly, when a drug can have unpleasant
side-effects , —- that feeling – jumpy to <sum><sum><sum><sum><sum>

(a psychologist from the University of Conn., who has teamed up with
Thomas
Moore.)

?: “It suggests that the frontline of treatment for depression should
be
psychological rather than chemical.”

Deborah Ames: “The problem is that good therapy is expensive and not
always available. Pills are cheaper and more easily available. Deborah
Ames, ABC News, New York.”

501 total views, 2 views today