“People often dismiss patient reports forgetting that peer reviewed research is NOT what causes drugs to be pulled from the market. Its purpose is to get drugs approved, not removed.
What got Thalidomide removed from the market? It was the cases of missing arms and legs of the babies born to the mothers of those who took the drug.
This statement on the importance of anecdotal evidence as opposed to peer reviewed double blind studies is from Dr. Johnathan Cole, MD who is considered to be the father of Psychopharmacology:
“The real world is not perfect. Drugs can and do cause adverse effects which can resemble the manifestations of the illness and arguments about the causes and nature of these adverse events, including suicides, must rest on case reports [anecdotal evidence] and data collected in small studies for other purposes. . . If some cases stand out strikingly, there are logically others where the adverse effect is more subtle.”
. . . Dr. Jonathan Cole, MD
- “Ann Blake-Tracy HAS BOLDY GONE WHERE FEW DARE TO TREAD!”…”BEST REFERENCE FOR ANTIDEPRESSANTS”…”BOLD & INFORMATIVE”… “PRICELESS”… “WELL DOCUMENTED”… “SCIENTIFICALLY RESEARCHED”… “WONDERFUL BOOK”
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- 1996 – Mutant Mice May Hold Key To Human Violence – An Excess Of Serotonin.
- 2/13/2002 • Psychiatrists shift the mood on antidepressants
- 2/17/1997 • Correlated reductions in cerebrospinal fluid 5-HIAA and MHPG concentrations after treatment with selective serotonin reuptake inhibitors.
- 2/28/2002 • Antidepressant drug trials turn away most of the depressed population
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- 2/7/2002 • Scandal of scientists who take money for papers ghostwritten by drug companies
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- 7/23/1996 • Effect of acute and chronic fluoxetine on extracellular dopamine levels in the caudate-putamen and nucleus accumbens of rat.
- 8/21/2003 • Research challenges role of antidepressants
- 8/8/1999 • Antidepressant discontinuation-related mania: critical prospective observation and theoretical implications in bipolar disorder.
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- 9/1/1999 • Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life
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