5/17/1975 • Fenfluramine in man: hypophagia associated with diminished serotonin turnover.

5/17/1975 • Fenfluramine in man: hypophagia associated with diminished serotonin turnover.

Shoulson I, Chase TN

Clin Pharmacol Ther 1975 May 17(5) 616-21

The results support the contention that the effect of fenfluramine on human dietary intake may be mediated by alterations in serotonergic rather than dopaminergic mechanisms.
Fenfluramine in man: hypophagia associated with diminished serotonin turnover.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1092516&dopt=Abstract

Shoulson I, Chase TN

Clin Pharmacol Ther 1975 May 17(5) 616-21

The results support the contention that the effect of fenfluramine on human dietary intake may be mediated by alterations in serotonergic rather than dopaminergic mechanisms.

A double-blind trial of orally administered fenfluramine was conducted in 7 non-obese adults with various neurological disorders. Caloric intake and body weight fell significantly after 8 days of treatment although there was no definite change in appetite ratings. Average central turnover of serotonin, as estimated by the cerebrospinal fluid (CSF) accumulation of 5-hydroxyindoleacetic acid (5-HIAA) during probenecid loading, decreased by 66%. No significant change in homovanillic acid, the major dopamine product, was apparent.
Publication Types: Clinical trial Controlled clinical trial PMID: 1092516, UI: 75148833

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